IndraLab

Statements

PRPF8 is phosphorylated. 21 / 21
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sparser
"We suggest that phosphorylation of eIF-4E is more complicated than previously recognized and that hyperphosphorylation of eIF-4E and p220 recruits more p220 into the protein complex that associates with mRNA caps."
8444875
sparser
"Treatment of MDCK-1 cells with the tyrosine kinase inhibitor herbimycin A reverted the cell phenotype to a more MDCK-like morphology in culture, with a concomitant reduction in the tyrosine phosphorylation predominantly of p220."
8886986
sparser
"When incubations were carried out in the presence of Mn" and low levels of Zn^, the phosphorylation of P180 and P220 was inhibited while the phosphorylation of P20 was not affected, thus sugg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"Phosphorylation of both the p25 and p220 subunits of eIF-4F is stimulated typically by 2.5-5-fold, with a 2-4-fold increase in phosphorylation of eIF-4B and eIF-3 p120."
2191953
sparser
"Moreover, anti-TNF-alpha antibodies inhibit LPS-stimulated phosphorylation of eIF-4E and p220 by 43% (+/- 6%) and 50% (+/- 5%), respectively."
1345341
sparser
"In reactions carried out in the absence of Zn^, resistant membranes contained phosphorylated P20, P180 and P220 (Fig. 2D) and proteins of similar molecular weights were either absent or present in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"Because insulin-like growth factor I stimulation of glucose uptake is not inhibited in cells with A/K1018 receptors while pp220 and pp170 phosphorylation is inhibited, it is unlikely that either pp220 or pp170 are involved in mediating the stimulation of glucose transport."
2153140
sparser
"Partial digests of phosphorylated p180 and p220 produced with chymotrypsin or V8 protease reveal that each protein has a distinct phosphopeptide pattern."
4063966
sparser
"To facilitate histone genes transcription during cell cycle cyclin E/CDK2 phosphorylates p220(NPAT) [ xref ]."
26059433
sparser
"P220, P180 and P20 were not phosphorylated in membranes from cells that had reverted to drug sensitivity, suggesting that these three proteins may have an important role in adriamycin resistance."
4062988
sparser
"Treatment of MDCK-1 cells with the tyrosine kinase inhibitor herbimycin A reverted the cell phenotype to a more MDCK-like morphology in culture, with a concomitant reduction in the tyrosine phosphorylation predominantly of p220."
8886986
sparser
"Treatment of cells with epidermal growth factor resulted in enhanced phosphorylation of both p28 (eIF-4E) and p220 subunits."
1993687
sparser
"Thus, eIF-4F p220, eIF-4B and ribosomal protein S6 are phosphorylated via PMA-dependent and insulin-dependent pathways, whereas phosphorylation of eIF-4F p25 and eIF-3 p120 is stimulated only upon activation of protein kinase C. Phosphopeptide maps of eIF-4F p220 and ribosomal protein S6 suggest that protease-activated kinase II is one of the protein kinases involved in the insulin-stimulated response in protein kinase C-depleted cells."
2191953
sparser
"In reactions carried out in the presence of Mn2+ and either 1.0 or 0.2mM Zn^, there was essentially a complete loss in the phosphorylation of either P180 or P220 in drug resistant membranes (Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
rlimsp
"Fibroblasts transformed in vitro by chemical carcinogens or SV40 virus and tumor-derived cancer cells of fibroblastoid or epithelioid origin usually express plastin and p220, a minor phosphorylated form of plastin."
4053036
sparser
"Pretreatment of cells with 1 microM okadaic acid resulted in the hyperphosphorylation of both p28 and p220 subunits."
1993687
sparser
"We report here that insulin-like growth factor I-stimulated phosphorylation of two endogenous substrate proteins, pp220 and pp170, is also inhibited in cells expressing A/K1018 receptors."
2153140
sparser
"In addition, okadaic acid-induced hyperphosphorylation of elF-4E and p220 results in the recruitment of more p220 protein into the cap- binding complex 1731."
7599274
sparser
"In contrast to the effect of Zn^ on P180 and P220 phosphorylation, there was essentially no inhibition of P20 phosphorylation in resistant membranes incubated with either 1 mM or 0.2mM Zn2^ (Fig. 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"Following treatment of reticulocytes with phorbol 12-myristate 13-acetate (PMA) for 30 min, stimulation of phosphorylation of both the p25 and p220 subunits was observed (2.5-5-fold)."
2914915
sparser
"To facilitate histone genes transcription during cell cycle cyclin E/CDK2 phosphorylates p220(NPAT) [ xref ]."
26059433