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Statements

PRPF8 is phosphorylated. 38 / 38
| 38
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"In addition, okadaic acid-induced hyperphosphorylation of elF-4E and p220 results in the recruitment of more p220 protein into the cap- binding complex 1731."
7599274
sparser
"Thus, eIF-4F p220, eIF-4B and ribosomal protein S6 are phosphorylated via PMA-dependent and insulin-dependent pathways, whereas phosphorylation of eIF-4F p25 and eIF-3 p120 is stimulated only upon activation of protein kinase C. Phosphopeptide maps of eIF-4F p220 and ribosomal protein S6 suggest that protease-activated kinase II is one of the protein kinases involved in the insulin-stimulated response in protein kinase C-depleted cells."
2191953
sparser
"This kinase was not inhibited by the cAMP-dependent protein kinase inhibitory peptide IAAGRTGRRNAIHDILVAA, did not phosphorylate $6 ribosomal protein, did not phosphorylate p220 of elF-4F as protein kinase C does and no other substrates for this kinase were apparent in reticulocyte ribosomal salt wash."
2967701
sparser
"Selective inhibition of p220 NPAT phosphorylation by CKIs at Subnuclear Foci."
19170105
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"To facilitate histone genes transcription during cell cycle cyclin E/CDK2 phosphorylates p220(NPAT) [ xref ]."
26059433
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"Partial digests of phosphorylated p180 and p220 produced with chymotrypsin or V8 protease reveal that each protein has a distinct phosphopeptide pattern."
4063966
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"Moreover, anti-TNF-alpha antibodies inhibit LPS-stimulated phosphorylation of eIF-4E and p220 by 43% (+/- 6%) and 50% (+/- 5%), respectively."
1345341
sparser
"We report here that insulin-like growth factor I-stimulated phosphorylation of two endogenous substrate proteins, pp220 and pp170, is also inhibited in cells expressing A/K1018 receptors."
2153140
sparser
"Addition of insulin to these down-regulated cells leads to stimulation of phosphorylation of eIF-4F p220, ribosomal protein S6, and to a lesser extent, eIF-4B; little or no stimulation of phosphorylation of eIF-4F p25 and eIF-3 p120 is observed."
2191953
sparser
"We have further found that p220 is phosphorylated specifically in M phase."
1327753
sparser
"Because insulin-like growth factor I stimulation of glucose uptake is not inhibited in cells with A/K1018 receptors while pp220 and pp170 phosphorylation is inhibited, it is unlikely that either pp220 or pp170 are involved in mediating the stimulation of glucose transport."
2153140
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"This spatial arrangement is tightly regulated in situ at the transcriptional level by the Cyclin E/CDK2 dependent phosphorylation of the p220 NPAT /HiNF-P promoter complex ( xref ; xref ; xref ; xref )."
19277982
sparser
"The principal pathway that activates histone H4 genes at the G1/S phase transition in somatic cells is the cyclin E/CDK2 dependent phosphorylation of the p220 NPAT co-activation complex."
22394165
sparser
"An autoradiogram of phosphoaminoacids and the locationof standards is shown here. contaminant that appeared to phosphorylate p220 of elF-4F (Fig. 2B, lanes 5-8)."
2967701
sparser
"We suggest that phosphorylation of eIF-4E is more complicated than previously recognized and that hyperphosphorylation of eIF-4E and p220 recruits more p220 into the protein complex that associates with mRNA caps."
8444875
sparser
"We investigated whether self-renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220 NPAT /HiNF-P complex to activate histone gene expression at the G1/S phase transition."
19890848
sparser
"Following treatment of reticulocytes with phorbol 12-myristate 13-acetate (PMA) for 30 min, stimulation of phosphorylation of both the p25 and p220 subunits was observed (2.5-5-fold)."
2914915
sparser
"P220 was phosphorylated on serine/threonine in PMA-stimulated Rat1 cells, and rPLD1 expressed in Sf9 cells was also serine/threonine phosphorylated in response to PMA treatment."
9703960
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"Interestingly, phosphorylation of both elF-4B and p220 occurs in response to insulin in PKC-downregulated 3T3-L1 cells."
1611042
sparser
"Moreover, p220 purified from interphase cells served as a good substrate for MAP kinase and MPF in vitro, and two-dimensional phosphopeptide mapping pattern of the p220 phosphorylated in vitro was very similar to that of p220 phosphorylated at M phase in vivo."
1327753
sparser
"Cyclin E arrives at these CBs during the G1/S transition and p220 is phosphorylated at 5 sites by the cyclinE/CDK2 kinase, enabling p220 to interact with and activate the histone H4 transcription fact[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18755223
sparser
"The kinase activity described here phosphorylates serine residue(s) of elF-4E and could be separated from kinases that phosphorylated p220 of eIF-4F 344 Vol."
2967701
sparser
"In reactions carried out in the absence of Zn^, resistant membranes contained phosphorylated P20, P180 and P220 (Fig. 2D) and proteins of similar molecular weights were either absent or present in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"In reactions carried out in the presence of Mn2+ and either 1.0 or 0.2mM Zn^, there was essentially a complete loss in the phosphorylation of either P180 or P220 in drug resistant membranes (Fig. [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"Although phosphorylation of p220 was regulated by cytoplasmic free calcium concentration ([Ca(2+)](i)), membrane depolarization alone was not sufficient to induce phosphorylation."
10567013
sparser
"Phosphorylation of p220 also was not directly mediated by protein kinase A, protein kinase C, or insulin exocytosis."
10567013
sparser
"In contrast to the effect of Zn^ on P180 and P220 phosphorylation, there was essentially no inhibition of P20 phosphorylation in resistant membranes incubated with either 1 mM or 0.2mM Zn2^ (Fig. 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"The primary amino acid sequence of BRCA1-IRIS retains many of the phospho-accepting sites phosphorylated in p220."
16860316
sparser
"The timing of p220 phosphorylation correlates with the appearance of cyclin E in CBs at the G1/S boundary, and this phosphorylation is maintained until prophase."
10995387
sparser
"Treatment of cells with epidermal growth factor resulted in enhanced phosphorylation of both p28 (eIF-4E) and p220 subunits."
1993687
sparser
"When incubations were carried out in the presence of Mn" and low levels of Zn^, the phosphorylation of P180 and P220 was inhibited while the phosphorylation of P20 was not affected, thus sugg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
4062988
sparser
"Pretreatment of cells with 1 microM okadaic acid resulted in the hyperphosphorylation of both p28 and p220 subunits."
1993687
sparser
"Treatment of MDCK-1 cells with the tyrosine kinase inhibitor herbimycin A reverted the cell phenotype to a more MDCK-like morphology in culture, with a concomitant reduction in the tyrosine phosphorylation predominantly of p220."
8886986
sparser
"P220, P180 and P20 were not phosphorylated in membranes from cells that had reverted to drug sensitivity, suggesting that these three proteins may have an important role in adriamycin resistance."
4062988
sparser
"It is known that p220, a major MAP of Xenopus, is phosphorylated by p34(cdc2) kinase as well as MAP kinase in mitotic cells, and that the phosphorylated p220 loses its MT-binding and -stabilizing abilities in vitro."
10069806
sparser
"Phosphorylation of both the p25 and p220 subunits of eIF-4F is stimulated typically by 2.5-5-fold, with a 2-4-fold increase in phosphorylation of eIF-4B and eIF-3 p120."
2191953
sparser
"Phosphorylation of p220(NPAT) at CDK dependent epitopes is most pronounced in S phase when cells exhibit elevated levels of cyclins E and A. Our data indicate that subnuclear organization of the HiNF-P/p220(NPAT) pathway is rapidly established as ES cells emerge from mitosis and that p220(NPAT) is subsequently phosphorylated in situ."
17520687
sparser
"elF-4B and p220 are also phosphorylated upon mitogenic stimulation of cells Initiation factors other than eIF-4E are also phosphorylated in response to growth factors and mitogens."
1611042