IndraLab

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"In contrast, the C-terminal Jab1 domain of the large spliceosomal PRPF8 scaffold that can activate the SNRNP200 helicase directly binds the active NC xref , xref ."

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"For crystallographic analyses, we used N-terminally truncated hBrr2 T1 in complex with the Jab1 domain of the hPrp8 protein lacking a Brr2-inhibiting C-terminal tail (hJab1 ΔC )."