IndraLab

Statements

PRPF8 binds SNRNP200. 13 / 13
7 | 1 5
biogrid
No evidence text available
23704370
biogrid
No evidence text available
22939629
biogrid
No evidence text available
27173435
biogrid
No evidence text available
16723661
sparser
"Moreover, they also report that a loss of PHF6 results in increased genomic instability at rDNA genes and a cell cycle delay at G2/M. While this was the first indication of a nucleolar function for PHF6, it has also been reported to interact with PRPF8 and SNRNP200, both constituents of the U4/U6-U5 tri-snRNP pre-mRNA splicing ribonucleoprotein complex [ xref ]."
26103525
sparser
"In addition, a small but reproducible reduction of SNRNP200 and PRPF8 binding was also observed in the case of the Δ201–250 deletion mutant."
34131137
biogrid
No evidence text available
26344197
biogrid
No evidence text available
17317632
biogrid
No evidence text available
16723661
reach
"The conservative missense variant p.PRPF8-Arg2310Lys that is not altering the global charge of the C-terminal tail, and variants located at the basis of the C-terminal tail show milder clinical phenotypes, in accordance with functional data on PRPF8 and SNRNP200 interactions in yeast."
29087248
sparser
"CryoEM structure of a BRR2-PRPF8 Jab1 -C9ORF78 complex."
35241646
sparser
"BRR2 interacts extensively with the U5-specific protein PRPF8 [ xref ]."
28076437
sparser
"All the known variants cluster in the C-terminal Jab1/MPN domain of the PRPF8 protein which interacts with SNRNP200 ( xref ; xref ; xref ; xref ; xref ; xref )."
33584830