IndraLab

Statements

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"Interestingly, we found a positive association of PRPF8 with chromosomal instability, which is in line with a previous study in osteosarcoma cells wherein PRPF8 silencing induces defects in Homologous Recombination (HR) through the specific inhibition of BRCA1 [54]."
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"Interestingly, we found a positive association of PRPF8 with chromosomal instability, which is in line with a previous study in osteosarcoma cells wherein PRPF8 silencing induces defects in Homologous Recombination (HR) through the specific inhibition of BRCA1 [54]."
39725737
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"Depletion of p53 binding protein 1 (53BP1) suppressed the HR defect induced by both BRCA1 loss and PRPF8 knockdown, suggesting that PRPF8 functions during HR at least in part via facilitating BRCA1 function."
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