IndraLab

Statements

SF3B4 binds PRPF8. 11 / 11
5 | 4 2
reach
"In addition, physical interactions between RBM39 and SF3A1/2/3, SF3B4, PRPF8 and MBNL1 have also been reported (Figure 5A) (10,83)."
36477312
biogrid
No evidence text available
22365833
biogrid
No evidence text available
22365833
biogrid
No evidence text available
28515276
reach
"A heatmap of the enrichment of snRNA-binding proteins showed validated patterns, with the specific binding of PRPF8 and SF3B4 to U4/5/6 and U2 snRNAs, respectively (Figure 5E)."
38955188
biogrid
No evidence text available
22365833
reach
"Utilizing the publicly available GnomAD32 database, we replicate findings where regions with known RBP function are more likely to contain rare (minor allele frequency [MAF] < 0.1%) and disruptive (Δln(LR) < −0.5) variants (Figure 7C, Mann-Whitney test p < 0.001).33 For example, rare variants disrupting SF3B4 and PRPF8 binding are enriched in proximal introns near 5′ SS and 3′ SS, respectively, resonating with the known splice-site-defining function of both spliceosomal proteins."
38955188
reach
"To explore potential combinatorial binding between SF3B4 and PRPF8, the likelihood of dual binding was juxtaposed with other clusters, encompassing those with solitary binding from either RBP."
38955188
biogrid
No evidence text available
35831314
sparser
"A heatmap of the enrichment of snRNA-binding proteins showed validated patterns, with the specific binding of PRPF8 and SF3B4 to U4/5/6 and U2 snRNAs, respectively ( xref E)."
38955188
sparser
"Utilizing the publicly available GnomAD xref database, we replicate findings where regions with known RBP function are more likely to contain rare (minor allele frequency [MAF] < 0.1%) and disruptive ( Δ ln(LR) < −0.5) variants ( xref C, Mann-Whitney test p  < 0.001). xref For example, rare variants disrupting SF3B4 and PRPF8 binding are enriched in proximal introns near 5′ SS and 3′ SS, respectively, resonating with the known splice-site-defining function of both spliceosomal proteins."
38955188