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Copper(2+) inhibits PRPF8. 2 / 2

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"Biologically relevant metal ions Cu 2+ and Zn 2+ at 0.5 mM and 2 mM respectively could inhibit splicing of the C. neoformans Prp8 intein in an in vitro Prp8 intein splicing assay, whereas Mg 2+ at 0.5 mM and 2 mM did not ."

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"Like other stressors known to inhibit RNA splicing, copper and zinc would act post-translationally to block Prp8 intein splicing and inhibit spliceosome function until levels of the metals are diminished by scavenger proteins or metal transporters [73]."

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Copper(2+) inhibits PRPF8. 2 / 2

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