IndraLab

Statements

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"Meanwhile, circRNA-UBAP2 represses apoptosis and contributes to the proliferation of ovarian cancer by miR-382-5p/PRPF8 axis (Xu et al., 2020)."
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"In ovarian cancer, PRPF8 expression significantly promotes ovarian cancer cell proliferation and inhibits apoptosis through the circRNA-UBAP2/miR-382-5p/PRPF8 pathway [69]."
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"In Drosophila, loss of PRPF8 decreases cell proliferation, increases cell death and modulates cell differentiation and polarity, and PRPF8-mediated hyperplastic growth is induced by different oncogenes ."
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"Silencing PRPF8 significantly reduced cell proliferation at 24–72 h in all cell lines tested (Fig. 3c)."
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"Alterations of PRPF8 increase the proliferation of CD34+ primary bone marrow cells and of a myeloid cell line, as well as resulting in defects of the second step of the RNA splicing process [58]."
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"( C ) The expression location of Prp8 was explored via immunofluorescence ( D ) CCK8 assay revealed that loss of Prp8 reduced cell proliferation ."
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"Indeed, in vitro PRPF8 silencing reduced the proliferation of different liver cancer cell lines through the modulation of important CDKs such as CDK2, reduced the migration capacity, and reduced the colony and tumorsphere formation capacity, all of which are important features related to the control of cancer stem cell viability and cancer progression."
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"We show that PRPF8 lesions lead to neomorphic spliceosomal activity and increased cellular proliferation resulting in a distinct phenotype of aggressive myeloid malignancies with increased RS."
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"CircRNA-UBAP2 can be used as a ceRNA of spongy miR-382-5p in ovarian cancer, increasing the expression level of PRPF8, promoting the proliferation of ovarian cancer cells, and inhibiting cell apoptosis (Xu et al., 2020)."
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"Consequently, circRNA-UBAP2 upregulated expression level of PRPF8 by sponged miR-382-5p acted as a ceRNA, promoted proliferation and inhibited apoptosis in ovarian cancer cells."
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"Taken together, these findings suggest that PRP8 leads to abnormal activation of HPASMC proliferation and glycolysis under hypoxia, which is achieved mainly through circNAP1L4.3.9 CircNAP1L4 alleviates SuHx-induced PH in mice."
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"Downregulation of PRPF8 promoted increased cell viability, proliferation, and clonogenicity of K-562 chronic myelogenous cells (CML) supporting PRPF8 as a tumor suppressor."
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