IndraLab

Statements

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"Meanwhile, circRNA-UBAP2 represses apoptosis and contributes to the proliferation of ovarian cancer by miR-382-5p/PRPF8 axis (Xu et al., 2020)."
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"CircRNA-UBAP2 can be used as a ceRNA of spongy miR-382-5p in ovarian cancer, increasing the expression level of PRPF8, promoting the proliferation of ovarian cancer cells, and inhibiting cell apoptosis (Xu et al., 2020)."
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"( C ) The expression location of Prp8 was explored via immunofluorescence ( D ) CCK8 assay revealed that loss of Prp8 reduced cell proliferation ."
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"Consequently, circRNA-UBAP2 upregulated expression level of PRPF8 by sponged miR-382-5p acted as a ceRNA, promoted proliferation and inhibited apoptosis in ovarian cancer cells."
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"We show that PRPF8 lesions lead to neomorphic spliceosomal activity and increased cellular proliferation resulting in a distinct phenotype of aggressive myeloid malignancies with increased RS."
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