IndraLab
Statements
reach
"Williams et al. also recently reported that USP1 and UAF1 deubiquitinates and prevents proteasomal degradation of ID (inhibitor of DNA binding) proteins, 13 which have been shown to activate multiple pathways involved in tumor progression, including preservation of the cancer stem cell phenotype."
USP1 affects hsFANCD2-Ub
|
8
USP1 affects hsFANCI-Ub
|
4
USP1 affects hsPCNA-Ub
|
3
USP1 affects monoubiquitinated-PCNA
|
2
USP1 affects mUb-PCNA
|
2
reach
"To further validate this point, experimental evidence has suggested that higher than normal levels of USP1 will inhibit the DNA damage induced monoubiquitination of USP1 targets, such as FANCD2, FANCI, and PCNA, whereas the loss of USP1 has been shown to cause chromosomal instability and elevated perinatal lethality in mice."
USP1 affects xlFANCD2-Ub
|
1
USP1 affects lane 3
|
1
USP1 affects hsFANCD2-Ub-FANCI
|
1
USP1 affects PCNA-mUb
|
1
USP1 affects Id1-3
|
1
USP1 affects Fig.S2B
|
1
USP1 affects Fanconi anemia complementation group I
|
1
USP1 affects Fanconi Anemia
|
1
USP1 affects FANCI-FANCD2
|
1
USP1 affects DNA-binding proteins 1–4
|
1