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Modified USP1 leads to the deubiquitination of USP1. 1 / 1

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"To further validate this point, experimental evidence has suggested that higher than normal levels of USP1 will inhibit the DNA damage induced monoubiquitination of USP1 targets, such as FANCD2, FANCI, and PCNA, whereas the loss of USP1 has been shown to cause chromosomal instability and elevated perinatal lethality in mice."

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IndraLab

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Modified USP1 leads to the deubiquitination of USP1. 1 / 1

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