IndraLab

Statements

USP1 deubiquitinates BCAT2 on K229. 5 / 5
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"USP1 deubiquitylates BCAT2 at the K229 site."
35663242
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"In addition, KRAS and USP1 can also regulate the expression of BCAT2 in PDAC through the ubiquitin-proteasome pathway: KRAS can stabilize the expression of BCAT2 in PDAC by inhibiting the ubiquitination of BCAT2 by spleen tyrosine kinase (SYK) and E3 ubiquitination ligase TRIM21, while USP1 deubiquitinates the K229 site of BCAT2, and BCAAs promote USP1 protein expression at the translation level through the GCN2-eIF2a pathway."
37699892
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"In turn, elevated USP1 deubiquitylates BCAT2 at the K229 site to stabilize BCAT2 protein."
35663242
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"Moreover, we screened with an available deubiquitylase library which contains 31 members of USP family and identified that USP1 deubiquitylates BCAT2 at the K229 site."
35663242
reach
"High concentrations of BCAA increase the translation of ubiquitin-specific peptidase 1 (USP1) by inhibiting the GCN2-eIF2α signalling pathway, and USP1 in turn deubiquitinates BCAT2 at the K229 site to stabilize its protein expression, leading to increased catabolism of BCAAs to promote PDAC cell proliferation [41]."
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