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USP1 deubiquitinates ID3. 4 / 5
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"For instance, USP1 slows osteosarcoma proliferation by deubiquitinating the inhibitors of DNA binding proteins (IDs) ID1, ID2, and ID3, in order to maintain a differentiated state in low-aggressive cells [111]."

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"Therefore, we sought a deubiquitinating enzyme that counters ID ubiquitination.We show that USP1 deubiquitinates and stabilizes ID1, ID2, and ID3, resulting in their increased abundance."

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"USP1 deubiquitinates and stabilizes the ID1, ID2, and ID3 proteins to preserve a mesenchymal stem cell (MSC) program in osteosarcoma [21] ."

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"USP1 also deubiquitinates and stabilizes the transcriptional regulators ID1, ID2 and ID3 [XREF_BIBR - XREF_BIBR]."