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USP1 deubiquitinates KIF11. 2 / 2
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"The results revealed that USP1 overexpression reduces K48-linked polyubiquitination of KIF11, while the K77R mutant of KIF11 does not undergo K48-linked polyubiquitination (Fig. 6G)."
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"These results suggest that USP1 plays a critical role in stabilizing KIF11 protein levels in hepatocellular carcinoma cells by removing ubiquitin modifications and preventing its degradation via the ubiquitin–proteasome pathway.To clarify the molecular mechanism by which USP1 deubiquitinates KIF11, we identified the interaction site between these proteins within the Kinesin Motor domain, specifically at the K77 residue, using truncation and lysine mutation experiments."
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