IndraLab

Statements

USP1 deubiquitinates CHEK1. 3 / 3
| 3
reach
"Multiple ubiquitin ligases, including the SKP1-CUL1-F-box (SCF) complex, CUL4-DDB1, and HUWE1 [ 89–93 ] can target CHK1 for proteasomal degradation, whereas the deubiquitinases USP1, USP3, USP7, and A[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33279370
reach
"Moreover, BRD7 knockdown specifically increased USP1 levels but had no effect on the levels of USP7 and ATXN3, suggesting that increased USP1 may deubiquitinate and stabilize CHK1 (Figs."
37626049
reach
"Interestingly, USP1 silencing only partially reversed the protein levels of CHK1 (Fig. 3B, lanes 3 versus 2 and 1) and totally reversed the protein half-life and ubiquitination of CHK1, which further indicates BRD7 could negatively regulate CHK1 transcription."
37626049