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USP1 deubiquitinates BRD4. 4 / 4
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"To examine whether USP1 deubiquitinated BRD4, we then set up in vivo and in vitro deubiquitination assay."
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"USP1 itself is also overexpressed in liver cancer and we show USP1 deubiquitinates BRD4 in vivo and in vitro, which increases BRD4 stability."
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"USP1 deubiquitinates and stabilizes BRD4."
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"IP-WB showed that USP1-KD indeed increased ubiquitination of BRD4 in different liver cancer cells (Fig. 3E)."
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