IndraLab

Statements


USP1 deubiquitinates PHLPP1. 2 / 2
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"USP1, similarly to USP12 and USP46, deubiquitinates AKT phosphatases PHLPP and PHLPPL [XREF_BIBR] and relies on UAF1 for its enzymatic activity, while it does not bind to WDR20 or any other additional proteins [XREF_BIBR]."

"<span class="match term0">USP1</span> [137] and USP46 [138] are other DUBs known to deubiquitinate <span class="match term1">PHLPP1</span>, with a similar outcome in other cancers as well."