IndraLab

Statements

USP1 deubiquitinates ubiquitinated FANCD2. 4 / 4
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"Furthermore, the USP1 and UAF1 complex can readily, and rapidly, de-ubiquitinate mono-ubiquitinated FANCD2 in an in vitro de-ubiquitination reaction [XREF_BIBR]."
19101576
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"Previous studies have shown that USP1 deubiquitylates mono-ubiquitinated PCNA (ub-PCNA) and mono-ubiquitinated FANCD2 (ub-FANCD2) in response to replication stress due to DNA damage during DNA replication (4, 5, 41)."
37478161
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"In addition, monoubiquitinated FANCD2/FANCI proteins are deubiquitinated by the USP1/UAF1 complex after DNA removal, completing the ICL repair procedure [42–45]."
37728310
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"USP1 is known to play a critical role in Fanconi anemia, complementation group A by deubiquitinating mono-ubiquitinated FANCD2 [19]."
38012162