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USP1 deubiquitinates ID1. 22 / 23
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"Recently, it has been shown that USP1, a ubiquitin specific protease, deubiquitinates ID1 and rescues it from proteasome degradation."
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"USP1 deubiquitinates and stabilizes the ID1, ID2, and ID3 proteins to preserve a mesenchymal stem cell (MSC) program in osteosarcoma [21] ."
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"USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma."
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"Once the lesion has been repaired, the ID complex is deubiquitinated by the USP1 and UAF1 complex, which also acts on monoubiquitinated PCNA when associated to the RFC subunit ELG1."
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"By deubiquitinating ID proteins, USP1 contributes to prevent bHLH mediated differentiation, and thus maintain stem-cell characteristics in osteosarcoma cells [XREF_BIBR]."
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"USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma."
26822809
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"One of the responsible mechanisms for OS pathogenesis is the deubiquitination of ID proteins by enzyme USP1, which helps maintain the OS cell stemness."
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"USP1 also deubiquitinates and stabilizes the transcriptional regulators ID1, ID2 and ID3 [XREF_BIBR - XREF_BIBR]."
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"Another piece of evidence for a tight coordination between the two pathways is the notion that the isopeptidase USP1 mediates deubiquitylation of both PCNA and the ID complex."
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"The FA ID complex is deubiquitinated by the UAF1 and USP1 complex."
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"USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program inosteosarcoma."
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"Therefore, we sought a deubiquitinating enzyme that counters ID ubiquitination.We show that USP1 deubiquitinates and stabilizes ID1, ID2, and ID3, resulting in their increased abundance."
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"USP1 can deubiquitinate ID1 (inhibitor of DNA binding 1), a transcription regulator, which was identified to control leukemogenesis by us previously, and protected ID1 from proteasome-mediated degradation [13]."
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"To identify a biological context in which USP1 deubiquitinates ID proteins, we examined USP1 expression patterns."
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"An ingenious investigation by Williams and colleagues found that the deubiquitinating enzyme USP1 conserved stem cell-like characteristics in osteosarcoma by stabilizing ID proteins and deubiquitinating ID proteins."
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"Within macrophages, USP1 deubiquitinates inhibitor of differentiation 1 (ID1) to sequester signal transducer and activator of transcription 1 (STAT1) in the cytoplasm, resulting in transcriptional downregulation of CD8 T-cell-recruiting factors (e.g., CCL4 and SerpinB2) (Fig. 1)."
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"As mentioned previously, USP1 inhibits CTL infiltration by deubiquitinating ID1 and suppressing the secretion of recruitment-related factors [19]."
38715050
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"The ID complex is deubiquitylated by USP1 whose activity is enhanced by the interaction with UAF1 ."
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"A deubiquitinating enzyme, USP1, has been implicated in deubiquitination of the ID complex ( Grompe and van de Vrugt, 2007 )."
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"67 In the present study, with the goal of identifying the mechanism by which USP1 executes its role in dedifferentiation, we considered the previously available information from literature which showed the deubiquitination of ID proteins by USP1 to be essential for maintenance of mesenchymal phenotype in osteosarcoma cells48 (Williams et al., 2011)."
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"For instance, USP1 slows osteosarcoma proliferation by deubiquitinating the inhibitors of DNA binding proteins (IDs) ID1, ID2, and ID3, in order to maintain a differentiated state in low-aggressive cells [111]."
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"Williams et al. also recently reported that USP1 and UAF1 deubiquitinates and prevents proteasomal degradation of ID (inhibitor of DNA binding) proteins, 13 which have been shown to activate multiple pathways involved in tumor progression, including preservation of the cancer stem cell phenotype."
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