The INDRA Database

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"Usp1 deubiquitinates FANCD2 and FANCI in the Falconi anemia pathway, promoting DNA repair."

26517048

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"Deubiquitination of FANCD2 and FANCI by USP1 in complex with UAF1 is also important for FA pathway function."

20417588

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"However, in addition to this opposition to activate and monoubiquitinate FANCD2/I, USP1 deubiquitination of FANCI has also been associated with promoting core complex recruitment to the site of DNA da[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

29198440

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"Indeed, USP1 is required for DNA damage induced FANCD2 foci formation [58-60] and FANCI de-ubiquitinated by USP1 is needed for efficient foci formation of the core complex [51]."

28552166

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"We showed that deubiquitination of FANCI by USP1 is an important step to recruit the FA core complex at sites of DNA damage."

26430909

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"More recent evidence suggests that a later deubiquitination of FANCD2 and FANCI by USP1 and UAF1 might be required for efficient foci assembly and HR mediated repair (J. Kim and A. D'Andrea, unpublished observation)."

18995829

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"When the repair process is completed, the FANCD2 and FANCI complex is deubiquitylated and dissociated from the repaired ICL site by the USP1 and UAF1 complex and is then released from the DNA [XREF_BIBR]."

33810518

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"The deubiquitination of FANCD2 and FANCI by the UAF1 and USP1 deubiquitinating enzyme complex appears to be required for the completion of the repair process [XREF_BIBR - XREF_BIBR]."

22737580

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"Indeed, USP1 knockdown delayed but did not abolish FANCI deubiquitination, as previously observed with similar timing (Nijman et al., 2005)."

34256011

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"Monoubiquitination or ATR dependent phosphorylation of FANCI were not required for the FA core complex recruitment, but FANCI deubiquitination by USP1 was."

26430909

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"USP1 influences accumulation of the Fanconi anaemia core complex at DNA damage sites and deubiquitylates FANCD2–FANCI in a cell cycle-dependent manner ."

28959952

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"Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling."

30456385

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"We have previously shown that USP1, in complex with its stimulatory binding partner, UAF1, deubiquitinates the Fanconi Anemia (FA) proteins, FANCD2 and FANCI."

24130053

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"Deubiquitination of FANCD2 and FANCI proteins by the multisubunit protein complex USP1 and UAF1 is required for the completion of the FA pathway."

28666371

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"Monoubiquitination or ATR-dependent phosphorylation of FANCI were not required for the FA core complex recruitment, but FANCI deubiquitination by USP1 was."

26430909

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"Deficiency of USP1 or FANCD2 promotes haematopoietic stem cells defects [50] , and siRNA knockdown experiments have shown that USP1 also deubiquitinates FANCI [48] , but whether this step is indispensable for ICL repair needs to be ascertained.The sliding clamp of DNA replication, also known as the proliferative cell nuclear antigen (PCNA), plays a leading role in the regulation of replicative lesion bypass (reviewed in [51] )."

27398234

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"The activated FA pathway must be inactivated for completion and recycling of the functional pathway, and this event is regulated by the USP1 and UAF1 deubiquitinating enzyme complex, which deubiquitinates FANCD2 and FANCI."

23624835

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"How USP1 eventually deubiquitinates the FANCD2 and FANCI complex following the completion of the DNA repair is still a question."

30831436

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"Deubiquitination of FANCI by USP1 is required for FA core complex foci formation."

26430909

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"The USP1 and UAF1 complex deubiquitylates FANCD2 and FANCI."