IndraLab

Statements

USP1 deubiquitinates FANCI. 25 / 27
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"Similarly, USP1, which plays an important role in DNA repair by specifically deubiquitylating FANCI/FANCD2 (I-D2), relies on UAF1 for allosteric activation and substrate recognition ( Cohn et al., 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34813758
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"We have previously shown that USP1, in complex with its stimulatory binding partner, UAF1, deubiquitinates the Fanconi Anemia (FA) proteins, FANCD2 and FANCI."
24130053
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"USP1 influences accumulation of the Fanconi anaemia core complex at DNA damage sites and deubiquitylates FANCD2–FANCI in a cell cycle-dependent manner ."
28959952
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"The USP1 and UAF1 complex deubiquitylates FANCD2 and FANCI."
20807115
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"How USP1 eventually deubiquitinates the FANCD2 and FANCI complex following the completion of the DNA repair is still a question."
30831436
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"Inhibition of USP1 increases monoubiquitination of both FANCD2 and FANCI, indicating further coordinate regulation at this level as well."
17488615
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"More recent evidence suggests that a later deubiquitination of FANCD2 and FANCI by USP1 and UAF1 might be required for efficient foci assembly and HR mediated repair (J. Kim and A. D'Andrea, unpublished observation)."
18995829
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"Indeed, USP1 is required for DNA damage induced FANCD2 foci formation [58-60] and FANCI de-ubiquitinated by USP1 is needed for efficient foci formation of the core complex [51]."
28552166
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"In the Fanconi anemia pathway, USP1 deubiquitinates FANCD2 and FANCI, two components of the Fanconi anemia complex, in order to facilitate DNA repair."
24717260
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"Monoubiquitination or ATR dependent phosphorylation of FANCI were not required for the FA core complex recruitment, but FANCI deubiquitination by USP1 was."
26430909
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"Deubiquitination of FANCI by USP1 is required for FA core complex foci formation."
26430909
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"The activated FA pathway must be inactivated for completion and recycling of the functional pathway, and this event is regulated by the USP1 and UAF1 deubiquitinating enzyme complex, which deubiquitinates FANCD2 and FANCI."
23624835
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"We showed that deubiquitination of FANCI by USP1 is an important step to recruit the FA core complex at sites of DNA damage."
26430909
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"Indeed, USP1 knockdown delayed but did not abolish FANCI deubiquitination, as previously observed with similar timing (Nijman et al., 2005)."
34256011
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"Usp1 deubiquitinates FANCD2 and FANCI in the Falconi anemia pathway, promoting DNA repair."
26517048
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"Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling."
30456385
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"For instance, it has been discovered that USP1-associated factor 1 (UAF1) and ubiquitin-specific peptidase 1 (USP1) deubiquitinate the proteins FANCD2, FANCI, and PCNA to control DDR."
38630271
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"For example, USP1 deubiquitinates FANCD2/FANCI or PCNA to prevent the recruitment of interstrand crosslink repair proteins and translesion DNA polymerase to inhibit DNA repair; USP7 regulates lung squamous cell carcinoma cell proliferation through MEK/ERK signaling by deubiquitinates the Raf-1 [175,176]."
37107644
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"However, in addition to this opposition to activate and monoubiquitinate FANCD2/I, USP1 deubiquitination of FANCI has also been associated with promoting core complex recruitment to the site of DNA da[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29198440
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"Deubiquitination of FANCD2 and FANCI by USP1 in complex with UAF1 is also important for FA pathway function."
20417588
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"When the repair process is completed, the FANCD2 and FANCI complex is deubiquitylated and dissociated from the repaired ICL site by the USP1 and UAF1 complex and is then released from the DNA [XREF_BIBR]."
33810518
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"The deubiquitination of FANCD2 and FANCI by the UAF1 and USP1 deubiquitinating enzyme complex appears to be required for the completion of the repair process [XREF_BIBR - XREF_BIBR]."
22737580
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"USP1 is well defined in its role in deubiquitinating monoubiquitylated PCNA [36] and Fanconi anemia pathways proteins, FANCD2 and FANCI [31, 32], to regulate the DNA damage response."
36798153
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"In addition, monoubiquitinated FANCD2/FANCI proteins are deubiquitinated by the USP1/UAF1 complex after DNA removal, completing the ICL repair procedure [42–45]."
37728310
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"Deubiquitination of FANCD2 and FANCI proteins by the multisubunit protein complex USP1 and UAF1 is required for the completion of the FA pathway."
28666371