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Statements

USP1 deubiquitinates ubiquitinated PCNA. 8 / 8
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"Ubiquitin-specific protease 1 (Usp1) is responsible for deubiquitinating monoubiquitinated PCNA [60] ."
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"Whether Usp1 is responsible for deubiquitinating polyubiquitinated PCNA remains to be determined, although one study did detect an elevated PCNA polyubiquitination upon Usp1 depletion [51] ."
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"Following DNA synthesis on damaged DNA templates by TLS polymerase (Mailand et al., 2013), the ubiquitinated PCNA is deubiquitinated by USP1, causing the release of TLS polymerases and re-association [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP1 (ubiquitin specific peptidase 1), which promotes de-ubiquitination of mono-ubiquitinated PCNA [57], forms a stable complex with UAF1 (USP1 associated factor 1), which stabilizes and activates USP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In vitro, the USP1 and UAF1 complex can de-ubiquitinate mono-ubiquitinated PCNA more efficiently than USP1 alone [59]."
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"USP1, an important negative regulator of the DNA damage tolerance pathway, deubiquitinates mono-ubiquitinated PCNA, (mUb-PCNA) [ 38 ]."
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"They observed an increased mutation frequency in cells in which USP1 was inactivated, a result expected if steady-state levels of monoubiquitinated PCNA are upregulated because of reduced deubiquitina[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Previous studies have shown that USP1 deubiquitylates mono-ubiquitinated PCNA (ub-PCNA) and mono-ubiquitinated FANCD2 (ub-FANCD2) in response to replication stress due to DNA damage during DNA replication (4, 5, 41)."
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