IndraLab

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USP1 deubiquitinates AKT. 8 / 8
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"As an AKT regulator, USP1 deubiquitinates AKT."
38132107
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"USP1, similarly to USP12 and USP46, deubiquitinates AKT phosphatases PHLPP and PHLPPL [XREF_BIBR] and relies on UAF1 for its enzymatic activity, while it does not bind to WDR20 or any other additional proteins [XREF_BIBR]."
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"For example, the Ubiquitin carboxyl-terminal hydrolase 7 (Usp7) regulates the subcellular localization of PTEN 28 and Usp1 deubiquitinates Akt 29."
35673573
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"USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation."
32133736
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"USP1 deubiquitinates AKT in vivo and cuts the ubiquitin chain at the Lys63 site of AKT, thus inhibiting PI3K-Akt signal transduction in B-cell acute lymphoblastic leukemia [185]."
37190313
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"Interestingly, USP1 was reported to regulate glucose uptake and muscle atrophy via deubiquitination of AKT during fasting [23]."
38012162
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"The results of the study by Dana Goldbraikh et al. showed that USP1 promoted the deubiquitination of Akt and reduced its phosphorylation level, while inhibition of USP1 promoted the activation of PI3K/Akt pathway [24]."
36859264
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"USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation."
32133736