IndraLab

Statements

USP1 deubiquitinates ID2. 9 / 10
1 | 9
reach
"Mechanically, we demonstrated that USP1 promoted GC metastasis via upregulating ID2 expression and further confirmed that USP1 stabilized ID2 expression through deubiquitinating ID2 in GC."
34873426
reach
"USP1 also deubiquitinates and stabilizes the transcriptional regulators ID1, ID2 and ID3 [XREF_BIBR - XREF_BIBR]."
28881649
reach
"It is presently unclear how USP1 catalyses de-ubiquitination of the ID2 complex as monoubiquitinated FANCI occludes the USP1 interaction site in FANCD2 ."
37591242
reach
"For instance, USP1 slows osteosarcoma proliferation by deubiquitinating the inhibitors of DNA binding proteins (IDs) ID1, ID2, and ID3, in order to maintain a differentiated state in low-aggressive cells [111]."
38534381
reach
"Therefore, we sought a deubiquitinating enzyme that counters ID ubiquitination.We show that USP1 deubiquitinates and stabilizes ID1, ID2, and ID3, resulting in their increased abundance."
21925315
reach
"To address whether USP1 deubiquitinated ID2 directly, ubiquitinated ID2 purified from 293T cells was incubated in vitro with either wild-type USP1 or USP1 C90S purified separately from 293T cells."
21925315
reach
"After participating in the FA pathway, the ID2 complex needs to be immediately de-ubiquitinated, which is mediated by the ubiquitin-specific peptidase USP1."
38846492
reach
"Similarly, USP1, which plays an important role in DNA repair by specifically deubiquitylating FANCI/FANCD2 (I-D2), relies on UAF1 for allosteric activation and substrate recognition ( Cohn et al., 200[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34813758
reach
"USP1 deubiquitinates and stabilizes the ID1, ID2, and ID3 proteins to preserve a mesenchymal stem cell (MSC) program in osteosarcoma [21] ."
29864528