IndraLab

Statements


USP1 deubiquitinates Ubiquitin. 3 / 3
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"Upon the induction of DNA damage, a fragment of USP1, ending in gly-gly, is produced, suggesting that USP1 “deubiquitinates” itself at an internal Ub-like region."

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"Wild-type USP1 that is autocleavage-inactive (G670A, G671A) deubiquitinated Ub–PCNA subunits, whereas catalytically inactive USP1 (C90S) did not."

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"These findings demonstrate that ATAD5-N modulates Ub–PCNA deubiquitination process directly and is crucial for UAF1–USP1 to efficiently deubiquitinate Ub–PCNA."