IndraLab

Statements

USP1 deubiquitinates BCAT2. 4 / 4
| 4
reach
"Next, we found that treatment with ML323, a specific inhibitor of USP1 [33], enhanced BCAT2 ubiquitylation (Fig. 2B) whereas USP1 wild-type but not enzyme-dead C90S mutant overexpression decreased BCAT2 ubiquitylation (Fig. 2C)."
35663242
reach
"Furthermore, USP1 knockdown enhanced ubiquitylation of the BCAT2 but not BCAT2 mutant (Fig. 3B)."
35663242
reach
"In contrast, ectopic USP1 expression decreased ubiquitylation of the BCAT2 but not BCAT2 mutant (Fig. 3C)."
35663242
reach
"BCAAs promote the expression of USP1 protein, and USP1 can deubiquitylate BCAT2."
37637065