IndraLab

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USP1 deubiquitinates hsPCNA-Ub. 3 / 3
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"The recombinant USP1 is able to fully deubiquitinate hsFANCD2-Ub, hsFANCI-Ub, and hsPCNA-Ub at sub-stoichiometric concentrations, in a UAF1-dependent manner (Fig 2D)."
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"As shown, USP1 –UAF1 readily deubiquitinates hsFANCD2-Ub, hsFANCI-Ub, and hsPCNA-Ub (Fig 3A)."
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"With the substrates purified (Fig 2C), we assessed whether hsFANCD2-Ub, hsFANCI-Ub, or hsPCNA-Ub is directly deubiquitinated by USP1–UAF1 in vitro."
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