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USP1 deubiquitinates SNAI1. 4 / 4
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"Here, we demonstrate that, following platinum treatment of OC cells, USP1 is able to de-ubiquitinate and stabilize Snail, eventually resulting in platinum resistance and metastatic dissemination of OC cells.Our work highlights a novel function of USP1, acting as a key factor that links platinum response to tumor spreading through the stabilization of Snail protein."
31086816
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"Once phosphorylated, USP1 binds to and deubiquitinates Snail, resulting in resistance to cisplatin and an increased metastatic potential [61]."
36240066
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"USP1 de-ubiquitinates and stabilizes Snail protein."
31086816
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"<span class="match term0">UBIQUITIN SPECIFIC PEPTIDASE 1</span> promotes hepatic fibrosis through positive regulation of CXCL1 by deubiquitinating <span class="match term1">SNAIL</span>"
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