IndraLab

Statements

USP1 deubiquitinates SNAI1. 3 / 4
1 | 3
reach
"Here, we demonstrate that, following platinum treatment of OC cells, USP1 is able to de-ubiquitinate and stabilize Snail, eventually resulting in platinum resistance and metastatic dissemination of OC cells.Our work highlights a novel function of USP1, acting as a key factor that links platinum response to tumor spreading through the stabilization of Snail protein."
31086816
reach
"Once phosphorylated, USP1 binds to and deubiquitinates Snail, resulting in resistance to cisplatin and an increased metastatic potential [61]."
36240066
reach
"USP1 de-ubiquitinates and stabilizes Snail protein."
31086816