IndraLab

Statements

USP1 deubiquitinates KDM4A. 4 / 4
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"A significant decrease in polyubiquitylated KDM4A protein was observed in cells transfected with GST fusion USP1, whereas GST fusion USP1 (CS) was not able to reduce KDM4A ubiquitination."
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"9, 27, 28 As KDM4A plays a key role in human cancer development, it is possible that in human cancers USP1 promotes the deubiquitination and stabilization of KDM4A."
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"3.4 USP1 deubiquitinates KDM4A."
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"USP1 deubiquitinates and stabilizes KDM4A, thereby promoting the binding of AR to the c-MYC gene enhancer."
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