IndraLab

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USP1 deubiquitinates ATG14. 4 / 4
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"USP1 promotes pancreatic cancer progression and autophagy by deubiquitinating ATG14."

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"USP1 deubiquitinates and stabilizes ATG14 protein."

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"Intriguingly, USP1 inhibition by SJB3-019A increased the ubiquitin level of ATG14 (Fig. 5J), indicating that USP1 deubiquitinates and stabilizes ATG14 protein."

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"USP1 deubiquitinates and stabilizes ATG14, thus remarkably promoting malignant features, such as cell proliferation, migration, autophagy, and tumor growth in PDAC."