IndraLab

Statements

USP1 leads to the deubiquitination of SHOX2. 3 / 3
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"Taken together, these results suggest that m6A-modified KIF9-AS1 promotes HCC chemoresistance via the deubiquitination of SHOX2 mediated by USP1."
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"Accordingly, we observed that USP1 suppression induced an increase in SHOX2 ubiquitination, leading to the downregulation of SHOX2 expression in HCC cells."
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"While SHOX2 is subjected to ubiquitination medicated degradation, USP1 enhances the deubiquitination of SHOX2, leading to high level of SHOX2 in HCC cells."
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