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USP53 affects cell population proliferation

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USP53 inhibits cell population proliferation.

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USP53 inhibits cell population proliferation. 10 / 21

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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"Overexpression of USP53 inhibited the proliferation and migration of HCC cells in vitro."

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"Taken together, USP53 inhibited the proliferation and migration of HCC cells by inducing the blocking at G1/S phases and increasing cell apoptosis."

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"Then, we performed immunohistochemical staining on the tissues of patients with renal clear cell carcinoma and found that the expression of USP53 in tumor tissues was significantly lower than paracancerous tissues (Figure 1F).3.2 Overexpression USP53 inhibits the growth and proliferation of ccRCC."

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"Through CCK‐8 assay, we found that overexpression of USP53 in Caki‐1 and 786‐O cells significantly inhibited cell proliferation (Figure 2C,D)."

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"BrdU cell proliferation assay was also used to test the proliferative ability of cells, and the proliferation of USP53 overexpression cells was inhibited compared with control (Figure 2G,H).3.3 Knockdown USP53 promotes the growth and proliferation of ccRCC."

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"In addition, USP53 also inhibited the proliferation and migration of clear renal cell carcinoma cells by inactivating the NF-κB pathway [9]."

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"The proliferation and metastasis of ccRCC were significantly inhibited by USP53 in vitro."

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"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."

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"Functionally, ectopic USP53 expression reduced cell proliferation and cell migration in vitro and vice versa."

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USP53 activates cell population proliferation.

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USP53 activates cell population proliferation. 10 / 11

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"Downregulation of USP53 also promote cell proliferation in vivo."

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"USP53 Promotes Cell Proliferation in TNBC."

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"The results showed that knockdown of USP53 significantly reduced TNBC cell proliferation (Figure 2c,d,g)."

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"Overexpression of USP53 accelerated TNBC cell proliferation (Figure 2f,h)."

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"As shown, the knockdown of USP53 significantly reduced the proliferation of mouse mammary tumors (Figure 2m)."

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"Taken together, USP53 inhibited HCC growth in vivo by impairing cell proliferation and enhancing cell apoptosis."

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"Because upregulation of USP53 promoted proliferation, migration, invasion, and EMT in TNBC, we investigated whether this was due to the regulation of CRKL by USP53."

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"Cell proliferation assays showed that USP53 knockdown inhibited cell proliferation and increased chemosensitivity to PTX in MDA-MB-231 cells (Figure 7c)."

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"Consistently, USP53 overexpression promoted cell proliferation and decreased chemosensitivity to PTX in MDA-MB-468 cells (Figure 7d)."

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"Functionally, USP53 promotes TNBC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT)."

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USP53 affects CRKL

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USP53 binds CRKL.

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CRKL binds USP53. 10 / 12

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"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."

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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."

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"Coimmunoprecipitation analysis showed that endogenous USP53 could bind CRKL ( xref l,m)."

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"Our study shows that USP53 can directly bind, stabilize, and deubiquitinate CRKL and further promote proliferation, migration, invasion, and EMT in TNBC.Recent research has demonstrated that CRKL can control EMT, impacting the development and spread of malignancies."

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"Taken together, USP53 can directly bind, stabilize, and deubiquitinate CRKL."

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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."

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"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."

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"We explored the STRING database to determine the precise mechanism by which USP53 controls EMT and discovered that USP53 can directly bind CRKL (Figure 4a)."

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"However, further study is needed to determine the sites by which USP53 interacts with CRKL and identify strategies that can be applied to regulate the degree of CRKL deubiquitination by USP53."

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No evidence text available

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USP53 deubiquitinates CRKL.

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USP53 deubiquitinates CRKL. 10 / 10

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"Overall, we discovered that USP53 deubiquitinates CRKL, encourages tumor development and metastasis, and reduces chemosensitivity in TNBC."

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"To date, the regulatory function of USP53 in EMT has not been made explicit.In this study, we verified that USP53 is a deubiquitinating enzyme for CRKL that directly binds, stabilizes, and deubiquitinates CRKL."

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"In conclusion, USP53 plays an important role in TNBC progression by deubiquitinating CRKL."

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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."

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"As a deubiquitinase, USP53 may control CRKL by deubiquitinating CRKL."

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"USP53 may regulate the proliferation and metastasis of TNBC by deubiquitinating CRKL."

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"Here, we found that CRKL can be deubiquitinated by USP53."

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"The overexpression of USP53 in TNBC promotes the deubiquitination of CRKL and tumor growth and metastasis in TNBC."

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USP53 activates apoptotic process. 10 / 16

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"USP53 induced apoptosis in HCC cells through stabilization of CYCS."

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"To further confirm whether USP53 induced cell apoptosis through CYCS, we simultaneously knocked down USP53 and overexpressed CYCS in HCC cells (Supplementary Fig. 3), and found the apoptotic rate was significantly enhanced compared to knocking down USP53 alone (Fig. 6C)."

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."

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"Of note, Usp53 is known to promote apoptosis , and Mrpl20 is a component of the mitoribosome complex, the dysfunction of which is liked to impair cell cycle processes ."

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"Finally, the overexpression of CYCS compensated for the decreased apoptotic rates in cells with USP53 knocked down, suggesting that USP53 induced the apoptosis in HCC cells through the deubiquitination of CYCS."

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"Zhao et al. showed that USP53 interacted with FKBP51 in lung adenocarcinoma cells, and induced apoptosis via the AKT pathway [8]."

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling ."

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"USP53 induces apoptosis of hepatocellular carcinoma cells through deubiquitination of cytochrome C [8] and is a tumor suppressive factor in esophageal carcinoma [9], lung adenocarcinoma [10], and renal clear cell carcinoma [11], but it has a significant inhibitory effect on the radiosensitivity of human cervical cancer [12]."

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"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

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USP53 inhibits apoptotic process.

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USP53 inhibits apoptotic process. 2 / 2

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"In their research, USP53, as a tumor suppressor, inhibited the proliferation and migration of Huh-7 and HCCLM3 cells in vitro, promoting apoptosis by deubiquitinating and stabilizing cytochrome C (a key apoptotic protein) to prolong its active time and restrained the growth of transplanted tumor in vivo."

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"Gain- and loss-of-function experiments demonstrated USP53 inhibited proliferation, clonogenesis, cell cycle and xenograft growth, as well as induced apoptosis and mitochondrial damage of breast cancer cells."

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USP53 affects CYCS

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USP53 binds CYCS.

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USP53 binds CYCS. 10 / 11

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"Finally, GST pull-down assay was used to verify the direct interaction between USP53 and CYCS (Fig. 4H)."

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"The experimental data obtained in this study also demonstrated that the binding between USP53 and CYCS occurred in the cytoplasm."

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"Finally, GST pull-down assay was used to verify the direct interaction between USP53 and CYCS (Fig. xref )."

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"As shown in Supplementary Fig. xref , USP53 interacted with CYCS and promotes the deubiquitination and stabilization of CYCS in HCC cells, which further activated the apoptosis cascade and inhibits the progression of tumors."

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"Furthermore, our experimental data showed that USP53 interacts with the CYCS protein."

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USP53 activates Neoplasm Metastasis. 8 / 8

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"The overexpression of USP53 in TNBC promotes the deubiquitination of CRKL and tumor growth and metastasis in TNBC."

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"USP53 Promotes TNBC Cell Metastasis."

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"Taken together, USP53 promotes metastasis and EMT in TNBC."

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"Here, we show that the deubiquitinase USP53 contributes to tumor growth and metastasis in TNBC."

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"Ubiquitin-specific peptidase 53 (USP53) prevents the inactivation of the NF-κB pathway by reducing ubiquitination of IκBα, thereby further inhibiting ccRCC proliferation and metastasis (Gui et al., 2021)."

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"In this study, we found that USP53 promoted the growth and metastasis of TNBC."

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"USP53 can inhibit the complex of p50 and p65 by deubiquitinizing IκBα, thereby inhibiting the activity of the NF-κB pathway and ultimately inhibiting the proliferation and metastasis of ccRCC [92]."

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"Additionally, the knockdown of USP53 suppressed proliferation, EMT, and metastasis and enhanced the paclitaxel response of TNBC cells."

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USP53 inhibits Neoplasm Metastasis.

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USP53 inhibits Neoplasm Metastasis. 4 / 4

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"The proliferation and metastasis of ccRCC were significantly inhibited by USP53 in vitro."

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"In summary, our data showed that USP53 inhibits ccRCC proliferation and metastasis through NF‐κB pathway inactivation."

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"In addition, USP53 knockdown promoted ccRCC growth and metastasis."

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"USP53 inhibited the proliferation and metastasis of ccRCC cells (786-O and Caki-1) via the NF-κB pathway in vitro, and the knockdown of USP53 promoted the growth of transplanted tumors in nude mice with ccRCC."

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CYCS affects USP53

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CYCS binds USP53.

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USP53 binds CYCS. 10 / 11

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No evidence text available

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"Finally, GST pull-down assay was used to verify the direct interaction between USP53 and CYCS (Fig. 4H)."

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"The experimental data obtained in this study also demonstrated that the binding between USP53 and CYCS occurred in the cytoplasm."

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"Finally, GST pull-down assay was used to verify the direct interaction between USP53 and CYCS (Fig. xref )."

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"Furthermore, our experimental data showed that USP53 interacts with the CYCS protein."

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CYCS activates USP53.

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CYCS activates USP53. 1 / 1

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"As shown in Fig. 5E, CYCS was upregulated in the cells overexpressing USP53."

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CRKL affects USP53

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CRKL binds USP53. 10 / 12

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"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."

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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."

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"Coimmunoprecipitation analysis showed that endogenous USP53 could bind CRKL ( xref l,m)."

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"Taken together, USP53 can directly bind, stabilize, and deubiquitinate CRKL."

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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."

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"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."

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"We explored the STRING database to determine the precise mechanism by which USP53 controls EMT and discovered that USP53 can directly bind CRKL (Figure 4a)."

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"However, further study is needed to determine the sites by which USP53 interacts with CRKL and identify strategies that can be applied to regulate the degree of CRKL deubiquitination by USP53."

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USP53 affects RIPK1

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USP53 binds RIPK1.

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USP53 binds RIPK1. 10 / 10

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"Targeting the USP53–RIPK1 axis could be a potential strategy for the treatment of alcohol-associated myocardial damage."

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"Our work elucidates the pathogenic role of the USP53–RIPK1 signaling axis in EtOH-induced cardiomyopathy, providing a novel molecular target for therapeutic intervention."

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"USP53 interacts with the intermediate domain of RIPK1 via its C-terminal region."

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"Cotransfection of USP53 mutants and HA-tagged RIPK1 in HEK-293T cells showed that both the full length and the C terminus of USP53 could interact with RIPK1, but not the N terminus of USP53, which indicated that the C terminus of USP53 was essential for interacting with RIPK1 (Fig. xref J)."

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"Subsequently, USP53 interacted with the intermediate domain of RIPK1 and removed K63-linked ubiquitination at lysine-377 (K377), facilitating RIPK1 phosphorylation and triggering downstream apoptotic and necroptotic pathways in cardiac cells."

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"USP53 directly binds to RIPK1 and triggers its kinase activity by removing the K63-linked ubiquitin chain at the lysine-377 (K377) site, which in turn drives apoptosis and necroptosis, and exacerbates ACM."

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"However, Co-IP assay revealed that the K377R mutation did not affect the interaction between RIPK1 and USP53 (Fig. xref G)."

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"These results highlight the USP53–RIPK1 signaling axis as a potential therapeutic target for mitigating ACM progression."

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"These findings revealed the critical role of USP53–RIPK1 interaction in driving alcoholic CM injury and ACM."

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"Mechanistically, USP53 directly interacts with RIPK1 and activates RIPK1 kinase activity by disrupting K63-linked ubiquitination at K377, the major K63 ubiquitination site in human RIPK1 [ xref ]."

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USP53 activates RIPK1.

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USP53 activates RIPK1. 1 / 1

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"These results suggest that USP53 activates RIPK1 by the deubiquitination of K63-linked Ub at K377 of RIPK1."

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USP53 affects Neoplasm Invasiveness

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USP53 inhibits Neoplasm Invasiveness.

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USP53 inhibits Neoplasm Invasiveness. 7 / 7

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"Therefore, it can be explained that the gene USP53 can inhibit the migration and invasion of renal cancer cells."

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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

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"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."

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"In the study of USP53-mediated IκB stabilization, researchers found that USP53 inhibits the proliferation, invasion, and migration of renal cancer cells in vitro and in vivo (53)."

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"The results showed that USP53 knockdown significantly promoted the migration and invasion of renal cancer cells Caki‐1 and 786‐O cells (Figure 5C,D)."

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"Wound-healing and transwell assays showed that the overexpressed USP53 significantly inhibited the migration (Fig. 2D–G) and invasion (Fig. 2H, I) of HCC cells in vitro."

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"EDU cell proliferation imaging assay and BrdU cell proliferation assay also showed that the proliferation of ccRCC after USP53 knockdown was promoted compare with shGFP (Figure 3E–H).3.4 Overexpression USP53 inhibits migration and invasion of ccRCC."

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USP53 activates Neoplasm Invasiveness.

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USP53 activates Neoplasm Invasiveness. 4 / 4

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"The ability of cell migration and invasion was tested via Transwell assays, we found fewer migrated cells on the Transwell chamber surface compared to the controls after overexpression USP53 (Figure 4C,D), the quantitative results are at the bottom of the picture.3.5 Knockdown USP53 promotes migration and invasion of ccRCC."

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"Functionally, USP53 promotes TNBC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT)."

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"Knockdown of CRKL Can Reverse Cell Proliferation, Migration, and Invasion Induced by USP53 Upregulation."

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"Because upregulation of USP53 promoted proliferation, migration, invasion, and EMT in TNBC, we investigated whether this was due to the regulation of CRKL by USP53."

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USP53 affects FBXO31

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USP53 binds FBXO31. 10 / 10

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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31ΔF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."

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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt and beta-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."

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"In addition to mediate β‐catenin directly, USP53 binding with FBXO31 further stabilizes β‐catenin in promotion of Wnt/β‐catenin activation in BMSCs and bone regeneration [ xref ]."

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"In addition to mediate β‐catenin directly, USP53 binding with FBXO31 further stabilizes β‐catenin in promotion of Wnt/β‐catenin activation in BMSCs and bone regeneration [143]."

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"Mass spectrometry showed that USP53 interacted with F-box only protein 31 (FBXO31) to promote proteasomal degradation of beta-catenin."

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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31DeltaF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."

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"As shown in Fig. xref , USP53 and FBXO31 bound with each other in hBMSCs."

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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt/β-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."

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FBXO31 binds CTNNB1, SKP1, and USP53. 1 / 1

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"First, we examined the mechanism through which FBXO31 regulated the stability of β-catenin, a key mediator of the Wnt signaling pathway xref and bone formation during osteogenic differentiation xref , using co-IP and western blot assays with wild-type FBXO31 and myc-FBXO31ΔF. As shown in Fig. xref , FBXO31 specifically interacted with β-catenin, Skp1, and USP53."

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USP53 affects TJP2

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USP53 binds TJP2.

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"Interactions of USP53 and TJP2 were investigated by immunofluorescence and co-immunoprecipitation."

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"USP53 interacts with TJP2."

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"It has been suggested that USP53 may interact with TJP2 and regulate its function in the liver."

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

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"Research in mice has demonstrated that USP53 interacts with TJP2 (ZO-2), contributing to the integrity of tight junctions (Figure xref )[ xref , xref ]."

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"USP53 interacts with the tight-junction constituent TJP2."

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"USP53 interacts with the tight-junction constituent TJP2."

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USP53 binds TJP1 and TJP2. 1 / 1

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"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

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USP53 activates TJP2.

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"Liver Usp53 cKO causes upregulation of hepatobiliary Tjp2, with biochemical and histologic features that largely mimic those of liver Tjp2 cKO, implying that USP53 deficiency may share similar mechanism to TJP2 deficiency."

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USP53 affects MSR1

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USP53 binds MSR1.

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USP53 binds MSR1. 3 / 3

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"Furthermore, Co-IP experiments confirmed endogenous and exogenous interactions between USP53 and SR-A."

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"This is consistent with our finding that USP53 interacts with, and deubiquitinates SR-A, thereby stabilizing SR-A and promoting the formation of SMC-derived foam cells."

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"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation ( xref )."

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"Thus, the physiological relevance of USP53-DDB2 interactions is unclear."

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"XREF_BIBR USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

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"For instance, USP9X influences apoptosis by targeting MCL-1 [ xref , xref ] or regulates TGFβ signaling via KDM4C [ xref ], while USP7 and USP24 target p53 [ xref , xref ], USP13 targets PTEN [ xref ], USP53 interacts with DNA damage binding protein 2 (DDB2) [ xref ], and USP28 modulates HIF-1α [ xref ]."

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"Damage-specific DNA binding protein 2 (DDB2) is involved in nucleotide excision repair, which can repair DNA damage, and prevent gene mutation and tumorigenesis. xref Zou et al showed that knockdown of DDB2 expression in human lung cancer cells decreases the G2 phase and the repair efficiency of homologous recombination to increase the sensitivity of lung cancer cells to radiotherapy. xref Damage-specific DNA binding protein has been shown to interact with USP53, although the physiological relevance of USP53–DDB2 interactions remains unclear. xref In this study, we knocked down USP53 to provide evidence that the relationship between USP53 and DDB2 increases the radiosensitivity of cervical squamous cell carcinoma."

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"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation (XREF_FIG)."

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"USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

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USP53 affects Cholestasis

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USP53 activates Cholestasis.

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USP53 activates Cholestasis. 7 / 7

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"Previous studies identified a new type of normal-GGT cholestasis caused by autosomal recessive pathogenic variants in ubiquitin-specific peptidase 53 (USP53)."

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"Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential cause of schizophrenia."

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene ( USP53 ) causing low-γ-GT (GGT) cholestasis."

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"Mutations in the USP53 gene in humans can cause cholestasis [4,5,6], hearing loss [7], and other conditions."

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"However, we cannot be sure that hepatic hemangiomas are the specific symptom of cholestasis caused by mutations in USP53 gene because they are the most common benign liver tumor, the incidence of which ranges from 0.4% to 20% of the total population."

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"Here, we report a novel truncating mutation in the ubiquitin-specific peptidase gene (USP53) causing low-gamma-GT (GGT) cholestasis."

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"In this study, we aimed to characterize clinical findings and biological insights on a novel USP53 splice variant causing cholestasis phenotype and provided a review of the literature."

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USP53 inhibits Cholestasis.

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USP53 inhibits Cholestasis. 3 / 3

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"However, how USP53 deficiency contributes to cholestasis is obscure."

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"Collectively, the results converge into a model in which loss of the USP53 catalytic activity reported herein causes pediatric cholestasis (Fig. 3)."

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"USP53 deficiency leads to cholestasis, and may be accompanied by hearing impairment or hearing loss in severe cases."

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RIPK1 affects USP53

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"Targeting the USP53–RIPK1 axis could be a potential strategy for the treatment of alcohol-associated myocardial damage."

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"Our work elucidates the pathogenic role of the USP53–RIPK1 signaling axis in EtOH-induced cardiomyopathy, providing a novel molecular target for therapeutic intervention."

40822127

➶

sparser

"USP53 interacts with the intermediate domain of RIPK1 via its C-terminal region."

40822127

➶

sparser

40822127

➶

sparser

40822127

➶

sparser

40822127

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sparser

"However, Co-IP assay revealed that the K377R mutation did not affect the interaction between RIPK1 and USP53 (Fig. xref G)."

40822127

➶

sparser

"These results highlight the USP53–RIPK1 signaling axis as a potential therapeutic target for mitigating ACM progression."

40822127

➶

sparser

"These findings revealed the critical role of USP53–RIPK1 interaction in driving alcoholic CM injury and ACM."

40822127

➶

sparser

"Mechanistically, USP53 directly interacts with RIPK1 and activates RIPK1 kinase activity by disrupting K63-linked ubiquitination at K377, the major K63 ubiquitination site in human RIPK1 [ xref ]."

40822127

DDB2 affects USP53

2 | 2 5

DDB2 binds USP53. 9 / 10

2 | 2 5

➶

sparser

"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation ( xref )."

23159851

➶

sparser

"Thus, the physiological relevance of USP53-DDB2 interactions is unclear."

23159851

➶

biogrid

No evidence text available

23159851

➶

reach

"XREF_BIBR USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

23159851

➶

biogrid

No evidence text available

23159851

➶

sparser

38702734

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sparser

32508265

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reach

"Interestingly, we also confirmed that USP53 interacts with DDB2 by co-immunoprecipitation (XREF_FIG)."

23159851

➶

sparser

"USP53 interacts with DDB2, but knockdown of USP53 has no effect on DDB2 stability."

23159851

ZMYND11 affects USP53

| 1 8

USP53 binds ZMYND11. 9 / 9

| 1 8

➶

sparser

"These results suggested that USP53 interacted with ZMYND11 and intercepted its ubiquitination in breast cancer cells."

39044157

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sparser

"Additionally, Meng X. et al. demonstrated that USP53 interacts with ZMYND11 to enhance its deubiquitination and stability, inhibiting breast cancer cell proliferation and inducing apoptosis [ xref ]."

40938895

➶

reach

"Co-immunoprecipitation data suggested that USP53 interacted with zinc finger MYND-type containing 11 (ZMYND11), and catalyzed its deubiquitination and stabilization."

39044157

➶

sparser

"Co-immunoprecipitation data suggested that USP53 interacted with zinc finger MYND-type containing 11 (ZMYND11), and catalyzed its deubiquitination and stabilization."

39044157

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sparser

"USP53-ZMYND11 axis may be a good potential biomarker or therapeutic target for breast cancer, which can provide novel insights into the diagnosis, treatment and prognosis."

39044157

➶

sparser

"USP53-ZMYND11 axis may be a potential breast cancer marker and therapeutic target."

39044157

➶

sparser

"ZMYND11 was Associated with USP53 and Breast Cancer Prognosis."

39044157

➶

sparser

"USP53 Interacted with ZMYND11 and Blocked its Ubiquitination."

39044157

➶

sparser

"Given the potential interaction between USP53 and ZMYND11, we determined the ZMYND11 level after USP53 changes."

39044157

TJP2 affects USP53

1 | 2 6

TJP2 binds USP53. 8 / 8

1 | 2 5

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sparser

"Interactions of USP53 and TJP2 were investigated by immunofluorescence and co-immunoprecipitation."

39705897

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sparser

"USP53 interacts with TJP2."

39705897

➶

sparser

"It has been suggested that USP53 may interact with TJP2 and regulate its function in the liver."

37324459

➶

biogrid

No evidence text available

34079125

➶

reach

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

29080116

➶

sparser

"Research in mice has demonstrated that USP53 interacts with TJP2 (ZO-2), contributing to the integrity of tight junctions (Figure xref )[ xref , xref ]."

40747224

➶

reach

"USP53 interacts with the tight-junction constituent TJP2."

32124521

➶

sparser

"USP53 interacts with the tight-junction constituent TJP2."

32124521

USP53 binds TJP1 and TJP2. 1 / 1

| 1

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sparser

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

29080116

USP53 affects cell differentiation

| 8

USP53 activates cell differentiation.

| 7

USP53 activates cell differentiation. 7 / 7

| 7

➶

reach

"We hypothesized that USP53 may positively regulate the osteogenic differentiation of hBMSCs in vitro and that local delivery of AAV2-USP53 to calvarial defects would thus enhance bone formation."

33664230

➶

reach

"USP53 has been found to promote osteogenic differentiation [3]."

37894400

➶

reach

"These results suggested that knockdown of USP53 decreased the osteogenic differentiation of hBMSCs."

33664230

➶

reach

"Overexpression of USP53 promoted the osteogenic differentiation of hBMSCs in vitro."

33664230

➶

reach

"Thus, USP53 positively regulated the osteogenic differentiation of hBMSCs."

33664230

➶

reach

"USP53 enhances osteogenic function and differentiation in human BMSCs by stabilizing key proteins associated with osteogenic differentiation and regulating the BMP signaling pathway."

38940355

➶

reach

"In addition, USP53 overexpression increased the level of active beta-catenin and enhanced the osteogenic differentiation of hBMSCs."

33664230

USP53 inhibits cell differentiation.

| 1

USP53 inhibits cell differentiation. 1 / 1

| 1

➶

reach

"Knockdown of USP53 inhibited the osteogenic differentiation of hBMSCs in vitro."

33664230

USP53 affects CTNNB1

1 | 6 1

USP53 activates CTNNB1.

| 3

USP53 activates CTNNB1. 3 / 3

| 3

➶

| 1

➶

reach

"In addition, USP53 overexpression increased the level of active beta-catenin and enhanced the osteogenic differentiation of hBMSCs."

33664230

USP53 affects Neoplasms

| 7

USP53 inhibits Neoplasms.

| 4

USP53 inhibits Neoplasms. 4 / 4

| 4

➶

reach

"Moreover, animal experiments demonstrated that USP53 overexpression inhibited tumor growth in nude mice [67]."

39300775

➶

reach

"Overexpression of USP53 reduced tumor growth in vivo."

35654790

➶

reach

39300775

➶

reach

"As shown in Fig. 3A–C, USP53 overexpression significantly decreased the growth rate and the tumor volume, which implied lower proliferative ability."

35654790

USP53 activates Neoplasms.

| 3

USP53 activates Neoplasms. 3 / 3

| 3

➶

reach

"The overexpression of USP53 in TNBC promotes the deubiquitination of CRKL and tumor growth and metastasis in TNBC."

37894400

➶

reach

"As shown, the knockdown of USP53 significantly reduced the proliferation of mouse mammary tumors (Figure 2m)."

37894400

➶

reach

"In addition, USP53 overexpression significantly decreased the percentage of Ki-67+ proliferating cells and increased that of TUNEL + apoptotic cells in the tumor tissues compared to the control (Fig. 3G–I)."

35654790

USP53 affects HYCC1

| 7

USP53 inhibits HYCC1.

| 4

USP53 inhibits HYCC1. 4 / 4

| 4

➶

reach

"Wound-healing and transwell assays showed that the overexpressed USP53 significantly inhibited the migration (Fig. 2D–G) and invasion (Fig. 2H, I) of HCC cells in vitro."

35654790

➶

reach

"Taken together, USP53 inhibited HCC growth in vivo by impairing cell proliferation and enhancing cell apoptosis."

35654790

➶

reach

"Taken together, USP53 inhibited the proliferation and migration of HCC cells by inducing the blocking at G1/S phases and increasing cell apoptosis."

35654790

➶

reach

"Overexpression of USP53 inhibited the proliferation and migration of HCC cells in vitro."

35654790

USP53 activates HYCC1.

| 3

USP53 activates HYCC1. 3 / 3

| 3

➶

reach

"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."

35654790

➶

reach

"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

35654790

➶

reach

"USP53 enhanced the apoptosis of HCC cells via deubiquitination of CYCS, and had a potential as a promising novel therapeutic target for HCC."

35654790

USP53 affects ccRCC

| 6

USP53 inhibits ccRCC.

| 5

USP53 inhibits ccRCC. 5 / 5

| 5

➶

reach

"In summary, USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway.3.7 Knockdown USP53 promotes the growth of ccRCC in vivo ."

33973730

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reach

"Moreover, USP53 knockdown promoted the ability of clone formation of ccRCC in vivo."

33973730

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reach

33973730

➶

reach

33973730

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reach

33973730

USP53 activates ccRCC.

| 1

USP53 activates ccRCC. 1 / 1

| 1

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reach

33973730

USP53 affects NFASC

| 6

USP53 inhibits NFASC.

| 4

USP53 inhibits NFASC. 4 / 4

| 4

➶

reach

"Here, we can guess that USP53 may inhibit the NF‐κB pathway by inhibiting the degradation of IκBα."

33973730

➶

reach

"We described a new mechanism by which USP53 inhibits ccRCC survival via the downregulation of the NF‐κB signaling pathway."

33973730

➶

reach

"USP53 (Ubiquitin specific peptidase 53) inhibits the initiation and progression of renal cell carcinoma by inhibiting activation of the nuclear factor κB (NF‐κB) pathway; it promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51‐AKT1 signaling [52, 53]."

35486664

➶

reach

"Furthermore, USP53 inhibited the progression of clear cell renal cell carcinoma by suppressing the nuclear factor κB (NF‐κB) pathway [9]."

35654790

USP53 activates NFASC.

| 2

USP53 activates NFASC. 2 / 2

| 2

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reach

"34 , 36 USP53 mediate NF‐κB signaling pathway is also used for verification in other tumor contexts."

33973730

➶

reach

"The regulation mechanism of USP53 mediated NF‐κB signaling pathway still needs to be explored then ascertain the functional effects of USP53 in ccRCC."

33973730

USP53 affects Flag

| 6

USP53 binds Flag. 6 / 6

| 6

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sparser

"In order to figure out why USP53 will affect the expression of IκBα, we transfected Myc‐ub, HA‐IκBα, and Flag‐USP53 into 293 cells, and then tested the effect of USP53 on the ubiquitination of IκBα by co‐immunoprecipitation and WB experiments."

33973730

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sparser

"We mutated lysine (K) to arginine (R) to generate point mutants of RIPK1, including HA-RIPK1-K302R, HA-RIPK1-K306R, HA-RIPK1-K316R, and HA-RIPK1-K377R. By cotransfection of Flag-USP53, Myc-Ub, and each RIPK1 mutant in HEK-293T cells, we observed that the K377R mutation effectively inhibited the USP53-induced RIPK1 deubiquitination, whereas K302R, K306R, and K316R did not affect this process (Fig. xref G)."

40822127

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sparser

"The results showed direct interaction between HA-RIPK1 and Flag-USP53 (Fig. xref E and F)."

40822127

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sparser

"Similar results were found in human embryonic kidney (HEK)-293T cells transfected with hemagglutinin (HA)-RIPK1 and Flag-USP53, which showed colocalization of HA-RIPK1 and Flag-USP53 in cytoplasm (Fig. xref D)."

40822127

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sparser

"By cotransfection of HA-RIPK1 with either Flag-USP53 or Flag-USP53-C41S in HEK-293T cells, we found that catalytic site-mutated USP53-C41S was unable to inhibit the ubiquitination of RIPK1 (Fig. xref B)."

40822127

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sparser

"By cotransfection of Flag-USP53 and RIPK1 mutants in AC16 cells, we observed that overexpression of USP53 significantly augmented EtOH-induced RIPK1 autophosphorylation, while K377R mutation effectively blocked the up-regulation of pRIPK1 Ser 166 mediated by USP53 (Fig. xref H and Fig. xref H)."

40822127

USP53 affects FKBP4

| 6

USP53 deubiquitinates FKBP4. 6 / 6

| 6

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reach

"Besides, USP53 could also induce cell apoptosis in lung adenocarcinoma cells through deubiquitinating FKBP51 [8]."

35654790

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reach

"Lung adenocarcinoma cells are regulated by USP53, which deubiquitinates FKBP51, dephosphorylates AKT1, and controls glycolysis and apoptosis [10]."

37894400

➶

reach

"Mechanistically, USP53 deubiquitinates FKBP51, which in turn dephosphorylates AKT1, and ultimately inhibits tumor growth in lung adenocarcinoma."

32511815

➶

reach

"USP53 is lowly expressed in lung adenocarcinoma, and USP53 deubiquitinates FKBP51, which thereby inhibits tumor growth in lung adenocarcinoma (72).2.5 Ubiquitination enzyme and the treatment of LC."

37795365

➶

reach

"As a tumour suppressor, USP53 can deubiquitinate FK506-binding protein 51 (FKBP51) to dephosphorylate AKT1 and inactivate downstream signalling pathways, thereby inhibiting the progression of LUAD (98)."

36969062

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reach

"USP53 deubiquitinated FKBP51 in lung adenocarcinoma cells (H1975 and HCC827), which, in turn, dephosphorylated AKT1, inducing cell apoptosis and inhibiting glycolysis through this signaling pathway."

39300775

USP53 affects EIF4A3

| 6

EIF4A3 binds USP53. 6 / 6

| 6

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sparser

"In this study, we found that EIF4A3 could interact with USP53 to stabilize its mRNA expression."

40481141

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sparser

"ENCORI software was used to analyze the upstream regulatory genes of USP53, and the results showed that USP53 interacted with EIF4A3 (Fig. xref A)."

40481141

➶

sparser

"Here, the ENCORI website predicted that USP53 interacted with EIF4A3."

40481141

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sparser

"USP53 level was enriched by anti-EIF4A3, indicating that EIF4A3 bound to the USP53 protein (Fig. xref B)."

40481141

➶

sparser

"The above results suggested that EIF4A3 interacted with USP53 to stabilize its mRNA expression."

40481141

➶

sparser

"EIF4A3 interacted with USP53."

40481141

Flag affects USP53

| 6

USP53 binds Flag. 6 / 6

| 6

➶

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33973730

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40822127

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"The results showed direct interaction between HA-RIPK1 and Flag-USP53 (Fig. xref E and F)."

40822127

➶

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40822127

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sparser

40822127

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sparser

40822127

EIF4A3 affects USP53

| 6

EIF4A3 binds USP53. 6 / 6

| 6

➶

sparser

"In this study, we found that EIF4A3 could interact with USP53 to stabilize its mRNA expression."

40481141

➶

sparser

"ENCORI software was used to analyze the upstream regulatory genes of USP53, and the results showed that USP53 interacted with EIF4A3 (Fig. xref A)."

40481141

➶

sparser

"Here, the ENCORI website predicted that USP53 interacted with EIF4A3."

40481141

➶

sparser

"USP53 level was enriched by anti-EIF4A3, indicating that EIF4A3 bound to the USP53 protein (Fig. xref B)."

40481141

➶

sparser

"The above results suggested that EIF4A3 interacted with USP53 to stabilize its mRNA expression."

40481141

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sparser

"EIF4A3 interacted with USP53."

40481141

Bisphenol A affects USP53

5 |

Bisphenol A increases the amount of USP53.

2 |

Bisphenol A increases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

| 1 1 3

➶

eidos

"USP53 also inhibits glycolysis , oxidative metabolism , and mitochondrial dynamics ."

34919659

➶

trips

"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

32511815

➶

reach

"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

32511815

➶

reach

"In addition, USP53 also suppressed glycolysis, oxidative metabolism, and mitochondrial dynamics."

39300775

➶

reach

"USP53 also inhibits glycolysis, oxidative metabolism, and mitochondrial dynamics."

34919659

USP53 affects SR-A

| 5

USP53 binds SR-A. 5 / 5

| 5

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"To explore whether USP53 interacts with SR-A, co-immunoprecipitation (Co-IP) and immunoblotting (IB) experiments were performed using HASMCs or HEK293T. The results showed that USP53 and SR-A efficiently co-immunoprecipitated (Figure xref E, 7F)."

38904030

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sparser

"These results demonstrate that USP53 interacts with SR-A, which can be enhanced by endothelial DKK1."

38904030

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sparser

"Furthermore, Co-IP experiments confirmed endogenous and exogenous interactions between USP53 and SR-A. These results suggest that USP53 may represent an intermediate molecular mechanism that mediates DKK1 to regulate the expression of SR-A in SMCs and influence the formation of foam cells."

38904030

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"Additionally, the interaction between USP53 and SR-A in HASMCs was enhanced by exogenous rDKK1 treatment (Figure xref G) or co-culturing with ECs overexpressing DKK1 (Lenti-GFP-DKK1 EC, Figure xref H)."

38904030

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"USP53 interacts with SR-A and regulates K48-linked polyubiquitination in SMCs, which may be enhanced by endothelial DKK1."

38904030

MSR1 affects USP53

| 5

MSR1 binds USP53.

| 4

USP53 binds MSR1. 3 / 3

| 3

➶

reach

"Furthermore, Co-IP experiments confirmed endogenous and exogenous interactions between USP53 and SR-A."

38904030

➶

reach

"This is consistent with our finding that USP53 interacts with, and deubiquitinates SR-A, thereby stabilizing SR-A and promoting the formation of SMC-derived foam cells."

38904030

➶

reach

"Additionally, the interaction between USP53 and SR-A in HASMCs was enhanced by exogenous rDKK1 treatment (Figure 7G) or co-culturing with ECs overexpressing DKK1 (Lenti-GFP-DKK1 EC, Figure 7H)."

38904030

USP53 binds MSR1 and USP domain. 1 / 1

| 1

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reach

38904030

MSR1 activates USP53.

| 1

MSR1 activates USP53. 1 / 1

| 1

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reach

"In addition, SR-A knockdown reduced the stimulatory effect of USP53 on SMC-derived foam cell formation (Figure 6M, 6N)."

38904030

H3K27 affects USP53

| 5

H3K27 activates USP53.

| 3

H3K27 activates USP53. 3 / 3

| 3

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ATF3 inhibits USP53. 3 / 3

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sparser

"Consequently, ATF3 might transcriptionally inactivate USP53 to repress adipocyte adipogenesis and downregulate the RhoA/ROCK pathway."

39641389

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"ATF3 suppresses 3T3-L1 adipocyte adipogenesis by transcriptionally repressing USP53."

| 4

➶

reach

"Additionally, the knockdown of USP53 suppressed proliferation, EMT, and metastasis and enhanced the paclitaxel response of TNBC cells."

37894400

➶

reach

"Because upregulation of USP53 promoted proliferation, migration, invasion, and EMT in TNBC, we investigated whether this was due to the regulation of CRKL by USP53."

37894400

➶

reach

"Taken together, USP53 promotes metastasis and EMT in TNBC."

37894400

➶

reach

"Functionally, USP53 promotes TNBC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT)."

37894400

USP53 affects TNFSF11

| 4

USP53 decreases the amount of TNFSF11.

| 3

USP53 decreases the amount of TNFSF11. 3 / 3

| 3

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reach

"Usp53 null mice displayed increased serum RANKL levels and Usp53 deficient osteoblasts and bone marrow adipocytes have increased expression of Rankl."

36726200

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reach

"Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis and functional activity of osteoclasts, and triggers osteodestructive diseases."

39300775

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reach

"It has been found that USP53 deficiency upregulates RANKL expression in osteoblasts and bone marrow adipocytes to support osteoclast production through the VDR-SMAD3 pathway and promotes bone marrow adipogenesis [61]."

39300775

USP53 activates TNFSF11.

| 1

USP53 activates TNFSF11. 1 / 1

| 1

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reach

"In addition, USP53 acting on the vitamin D-receptor-SMAD3 pathway increases RANKL-dependent osteoclastogenesis through osteoblasts (71)."

38940355

USP53 affects TNBC

| 4

USP53 activates TNBC. 4 / 4

| 4

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"Functionally, USP53 promotes TNBC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT)."

37894400

➶

reach

"USP53 Promotes TNBC Cell Metastasis."

37894400

➶

reach

"In this study, we found that USP53 promoted the growth and metastasis of TNBC."

37894400

➶

reach

"Overexpression of USP53 accelerated TNBC cell proliferation (Figure 2f,h)."

37894400

USP53 affects NFKB1

| 1 3

USP53 inhibits NFKB1. 4 / 4

| 1 3

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sparser

"In summary, USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway."

33973730

➶

sparser

39300775

➶

sparser

"USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway."

33973730

➶

reach

39300775

USP53 affects Deafness

| 4

USP53 activates Deafness.

| 3

USP53 activates Deafness. 2 / 2

| 2

➶

reach

"Mutations in the USP53 gene can cause cholestasis and deafness and may also be a potential cause of schizophrenia."

39300775

➶

reach

"USP53 encodes a protein of uncertain function and USP53 deficiency causes deafness in mice."

"Furthermore, USP53 inhibited the progression of clear cell renal cell carcinoma by suppressing the nuclear factor κB (NF‐κB) pathway [9]."

35654790

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reach

"Ubiquitin-specific peptidase 53 inhibits the occurrence and development of clear cell renal cell carcinoma through NF-kappaB pathway inactivation."

33973730

➶

reach

"In addition, USP53 also inhibited the proliferation and migration of clear renal cell carcinoma cells by inactivating the NF-κB pathway [9]."

35654790

Methylmercury chloride affects USP53

3 |

Methylmercury chloride decreases the amount of USP53. 3 / 3

3 |

➶

ctd

No evidence text available

28001369

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

23179753

USP53 affects cellular respiration

| 1 2

USP53 inhibits cellular respiration. 3 / 3

| 1 2

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reach

"In addition, USP53 also suppressed glycolysis, oxidative metabolism, and mitochondrial dynamics."

39300775

➶

eidos

"USP53 also inhibits glycolysis , oxidative metabolism , and mitochondrial dynamics ."

34919659

➶

reach

"USP53 also inhibits glycolysis, oxidative metabolism, and mitochondrial dynamics."

34919659

USP53 affects cell growth

| 3

USP53 inhibits cell growth.

| 2

USP53 inhibits cell growth. 2 / 2

| 2

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reach

"Our study reveals that USP53 is activated by H3K27 acetylation and suppresses ESCA progression by regulating cell growth and metabolism."

34919659

➶

reach

"USP53 gene has been associated with some models of tumorigenesis:–In clear cell renal cell carcinoma inhibits the occurrence and development of cancer through NF-κB pathway inactivation [93];–In cervical squamous cell carcinoma correlated with the sensitivity to radiotherapy [94];–In oesophagal carcinoma, USP53 suppresses cancer progression by regulating cell growth and metabolism [95];–In lung adenocarcinoma, USP53 regulates cell apoptosis and glycolysis through the AKT1 pathway acting as a tumour suppressor [96]."

35884482

USP53 activates cell growth.

1 | 2

USP53 deubiquitinates NFKBIA.

1 | 1

USP53 leads to the deubiquitination of NFKBIA. 2 / 2

1 | 1

➶

1 | 2

USP53 increases the amount of CDH1.

3 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP53.

2 |

2,3,7,8-tetrachlorodibenzodioxine increases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

33387578

➶

ctd

No evidence text available

18691609

2,3,7,8-tetrachlorodibenzodioxine decreases the amount of USP53.

ctd

No evidence text available

34492290

Sodium arsenite affects USP53

2 |

Sodium arsenite decreases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

37682722

➶

ctd

No evidence text available

34032870

RDKK1 affects USP53

| 2

RDKK1 activates USP53. 2 / 2

| 2

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reach

"Furthermore, the upregulation of USP53 induced by rDKK1 was markedly reversed by CREB siRNA (Figure S11D)."

38904030

➶

2 |

➶

ctd

No evidence text available

26690555

➶

ctd

No evidence text available

33387578

Hsa-miR-16-5p affects USP53

2 |

Hsa-miR-16-5p decreases the amount of USP53. 2 / 2

2 |

➶

biopax:mirtarbase

No evidence text available

20371350

➶

2 |

➶

ctd

No evidence text available

30319688

➶

ctd

No evidence text available

23378141

Dexamethasone affects USP53

2 |

Dexamethasone increases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

28628672

➶

2 |

➶

ctd

No evidence text available

38174414

➶

ctd

No evidence text available

37325564

Bisphenol F affects USP53

2 |

Bisphenol F increases the amount of USP53. 2 / 2

2 |

➶

ctd

No evidence text available

38685157

➶

2 |

➶

biogrid

No evidence text available

29119051

➶

biogrid

No evidence text available

29119051

USP53 affects metabolic process

| 2

| 1

➶

sparser

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

29080116

USP53 binds TJP1. 1 / 1

| 1

➶

reach

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

29080116

USP53 affects SLPI

| 2

USP53 activates SLPI. 2 / 2

| 2

➶

reach

"Additionally, knockdown of USP53 decreased ALP and Alizarin Red S staining intensity as well as ALP activity."

33664230

➶

reach

"Overexpression of USP53 enhanced ALP and Alizarin red S staining intensity as well as ALP activity."

33664230

USP53 affects S

2 |

S binds USP53. 1 / 1

1 |

➶

| 1

➶

sparser

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex (Kazmierczak et al., xref )."

29080116

USP53 binds TJP1. 1 / 1

| 1

➶

reach

"Instead of binding with Ub, USP53 interacts with ZO-1 and ZO-2 as a part of the tight junction complex."

29080116

S affects USP53

2 |

S binds USP53. 1 / 1

1 |

➶

| 1

DKK1 inhibits USP53. 1 / 1

| 1

➶

reach

"DKK1 inhibits proteasomal degradation of SR-A by upregulating USP53."

38904030

DKK1 activates USP53.

| 1

DKK1 activates USP53. 1 / 1

| 1

➶

reach

"In addition, by using co-culture system, we found that knockdown of endothelial DKK1 inhibited the LowSS-induced upregulation of USP53 in co-cultured SMCs (Figure S9J)."

38904030

CTNNB1 affects USP53

1 | 1

FBXO31 binds CTNNB1, SKP1, and USP53. 1 / 1

| 1

➶

sparser

| 1

| 1

| 1

➶

reach

38831454

USP53 affects Carcinoma, Hepatocellular

| 1

31173147