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USP53 leads to the ubiquitination of MSR1. 2 / 2

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"To test whether USP53 modulates SR-A ubiquitination, HEK293T cells were co-transfected with HA-tagged ubiquitin (Ub), Myc-tagged SR-A, and dose-dependent Flag-tagged USP53 plasmids."

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"In addition, by using co-culturing HASMCs transfected with USP53-siRNA and HAECs transfected with Lenti-GFP-DKK1, we found that USP53 knockdown reversed the downregulation of SR-A ubiquitination induced by endothelial DKK1 in co-cultured HASMCs (Figure 7L)."

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USP53 leads to the ubiquitination of MSR1. 2 / 2

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