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USP53 deubiquitinates CYCS. 3 / 3
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"USP53 also deubiquitinates cytochrome c and promotes apoptosis of hepatoma cells [8]."
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"Ubiquitination CO-IP further showed that overexpression of USP53 led to deubiquitination of CYCS in the HEK-293T, Huh-7 and HCCLM3 cells (Fig. 5M)."
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"As shown in Supplementary Fig. 5, USP53 interacted with CYCS and promotes the deubiquitination and stabilization of CYCS in HCC cells, which further activated the apoptosis cascade and inhibits the progression of tumors."
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