IndraLab
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"This is important to emphasize to have PFIC4 patients with native liver adequately screened.Patients with less frequent, novel, and yet not fully understood types of PFIC-associated genetic mutations (eg, nuclear receptor subfamily 1 group H, MYO5B, KIF12, lipolysis stimulated lipoprotein receptor, ubiquitin-specific peptidase 53, and WD repeat domain 83 opposite strand gene) were not included in this study.This systematic review has certain limitations that are, to some extent, based on the rarity of the diseases included."