IndraLab

Statements

USP53 deubiquitinates FKBP4. 6 / 6
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"USP53 is lowly expressed in lung adenocarcinoma, and USP53 deubiquitinates FKBP51, which thereby inhibits tumor growth in lung adenocarcinoma (72).2.5 Ubiquitination enzyme and the treatment of LC."
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"As a tumour suppressor, USP53 can deubiquitinate FK506-binding protein 51 (FKBP51) to dephosphorylate AKT1 and inactivate downstream signalling pathways, thereby inhibiting the progression of LUAD (98)."
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"USP53 deubiquitinated FKBP51 in lung adenocarcinoma cells (H1975 and HCC827), which, in turn, dephosphorylated AKT1, inducing cell apoptosis and inhibiting glycolysis through this signaling pathway."
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"Besides, USP53 could also induce cell apoptosis in lung adenocarcinoma cells through deubiquitinating FKBP51 [8]."
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"Lung adenocarcinoma cells are regulated by USP53, which deubiquitinates FKBP51, dephosphorylates AKT1, and controls glycolysis and apoptosis [10]."
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"Mechanistically, USP53 deubiquitinates FKBP51, which in turn dephosphorylates AKT1, and ultimately inhibits tumor growth in lung adenocarcinoma."
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