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"To further confirm whether USP53 induced cell apoptosis through CYCS, we simultaneously knocked down USP53 and overexpressed CYCS in HCC cells (Supplementary Fig. 3), and found the apoptotic rate was significantly enhanced compared to knocking down USP53 alone (Fig. 6C)."

"USP53 induced apoptosis in HCC cells through stabilization of CYCS."

"Zhao et al. showed that USP53 interacted with FKBP51 in lung adenocarcinoma cells, and induced apoptosis via the AKT pathway [8]."

"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling ."

"USP53 induces apoptosis of hepatocellular carcinoma cells through deubiquitination of cytochrome C [8] and is a tumor suppressive factor in esophageal carcinoma [9], lung adenocarcinoma [10], and renal clear cell carcinoma [11], but it has a significant inhibitory effect on the radiosensitivity of human cervical cancer [12]."

"USP53 promotes apoptosis and inhibits glycolysis in lung adenocarcinoma through FKBP51-AKT1 signaling."

"USP53 enhanced the apoptosis of HCC cells via deubiquitination of CYCS, and had a potential as a promising novel therapeutic target for HCC."

"OSBPL1A is recognized as an immune- and cancer-associated fibroblast (CAF)-related gene in colorectal cancer , SPINK4 inhibits ferroptosis and promotes tumor growth , P4HA1 protects nasopharyngeal carcinoma cells from erastin-induced ferroptosis by activating HMGCS1 , PSMD12 may activate the MEK-ERK pathway via KIF15 upregulation, thereby promoting tumor progression , ADAM9 is highly expressed in various cancers, including non-small cell lung, pancreatic, gastric, breast, ovarian, and colorectal cancers , and USP53 induces apoptosis in hepatocellular carcinoma cells through the deubiquitination of cytochrome c ."

"Taken together, USP53 inhibited the proliferation and migration of HCC cells by inducing the blocking at G1/S phases and increasing cell apoptosis."

"With the gradual decrease in the expression of E-cadherin, USP53, which was upregulated in tumour cell (Supplementary Figure S13C), could promote apoptosis through FKBP51-AKT1 signalling [37]."

"Taken together, USP53 inhibited HCC growth in vivo by impairing cell proliferation and enhancing cell apoptosis."

"As reported previously, USP53 induced the apoptosis of lung adenocarcinoma cells through deubiquitination of FKBP51 [8]."

"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."

"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."

"Of note, Usp53 is known to promote apoptosis , and Mrpl20 is a component of the mitoribosome complex, the dysfunction of which is liked to impair cell cycle processes ."

"Finally, the overexpression of CYCS compensated for the decreased apoptotic rates in cells with USP53 knocked down, suggesting that USP53 induced the apoptosis in HCC cells through the deubiquitination of CYCS."