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USP53 inhibits cell population proliferation. 21 / 21
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"Furthermore, the ectopic expression of USP53 inhibited the proliferation, migration and invasion, and induced the apoptosis of HCC cells."
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"Overexpression of USP53 inhibited the proliferation and migration of HCC cells in vitro."
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"Taken together, USP53 inhibited the proliferation and migration of HCC cells by inducing the blocking at G1/S phases and increasing cell apoptosis."
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"Then, we performed immunohistochemical staining on the tissues of patients with renal clear cell carcinoma and found that the expression of USP53 in tumor tissues was significantly lower than paracancerous tissues (Figure 1F).3.2 Overexpression USP53 inhibits the growth and proliferation of ccRCC."
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"Through CCK‐8 assay, we found that overexpression of USP53 in Caki‐1 and 786‐O cells significantly inhibited cell proliferation (Figure 2C,D)."
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"BrdU cell proliferation assay was also used to test the proliferative ability of cells, and the proliferation of USP53 overexpression cells was inhibited compared with control (Figure 2G,H).3.3 Knockdown USP53 promotes the growth and proliferation of ccRCC."
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"In addition, USP53 also inhibited the proliferation and migration of clear renal cell carcinoma cells by inactivating the NF-κB pathway [9]."
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"The proliferation and metastasis of ccRCC were significantly inhibited by USP53 in vitro."
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"Furthermore, forced expression of USP53 inhibited the proliferation, migration and invasion, and induced apoptosis in HCC cell lines both in vitro and in vivo."
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"Functionally, ectopic USP53 expression reduced cell proliferation and cell migration in vitro and vice versa."
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"Our data indicate that USP53 inhibits cancer cell proliferation and migration."
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"In the study of USP53-mediated IκB stabilization, researchers found that USP53 inhibits the proliferation, invasion, and migration of renal cancer cells in vitro and in vivo (53)."
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"In summary, our data showed that USP53 inhibits ccRCC proliferation and metastasis through NF‐κB pathway inactivation."
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"USP53 inhibited the proliferation and metastasis of ccRCC cells (786-O and Caki-1) via the NF-κB pathway in vitro, and the knockdown of USP53 promoted the growth of transplanted tumors in nude mice with ccRCC."
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"USP53 can inhibit the complex of p50 and p65 by deubiquitinizing IκBα, thereby inhibiting the activity of the NF-κB pathway and ultimately inhibiting the proliferation and metastasis of ccRCC [92]."
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"CCK8 and clonal formation experiments suggested that overexpression of USP53 can inhibit the proliferation and clonogenesis of HCT116 colorectal cancer cells in vitro."
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"In their research, USP53, as a tumor suppressor, inhibited the proliferation and migration of Huh-7 and HCCLM3 cells in vitro, promoting apoptosis by deubiquitinating and stabilizing cytochrome C (a key apoptotic protein) to prolong its active time and restrained the growth of transplanted tumor in vivo."
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"Gain- and loss-of-function experiments demonstrated USP53 inhibited proliferation, clonogenesis, cell cycle and xenograft growth, as well as induced apoptosis and mitochondrial damage of breast cancer cells."
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"Ubiquitin-specific peptidase 53 (USP53) prevents the inactivation of the NF-κB pathway by reducing ubiquitination of IκBα, thereby further inhibiting ccRCC proliferation and metastasis (Gui et al., 2021)."
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"Cheng et al. [60] reported that USP53 inhibited the proliferation and growth of esophageal carcinoma cells in vitro and in vivo, and that USP53 activation by H3K27 acetylation modulates cell viability via the AMPK signaling pathway."
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"USP53 suppresses the proliferation and growth of ESCA cells in vitro and in vivo, whereas its knockdown exerts opposite effects."
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