IndraLab

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USP53 activates CTNNB1. 3 / 3
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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt and beta-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."
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"In vitro ubiquitination assays showed that beta-catenin degradation was significantly reduced by USP53 overexpression in a concentration dependent manner, whereas downregulation of USP53 promoted the degradation of beta-catenin."
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"Moreover, USP53 increased the half-life of active beta-catenin compared with that in the control group."
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