IndraLab

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USP53 deubiquitinates MSR1. 2 / 2
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"This is consistent with our finding that USP53 interacts with, and deubiquitinates SR-A, thereby stabilizing SR-A and promoting the formation of SMC-derived foam cells."
38904030
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"Endogenous and exogenous ubiquitination, in addition to in vitro ubiquitination assays, have revealed that SR-A is deubiquitinated by USP53 through its deubiquitinating enzyme via K48-linked polyubiquitination, which inhibits protein degradation via the 26S proteasome pathway.Thus, herein, we demonstrate that low shear stress-induced endothelial DKK1 promotes the formation of co-cultured SMC-derived foam cells, which is primarily mediated by the USP53-inhibited proteasomal degradation of SR-A."
38904030