IndraLab

Statements

USP53 deubiquitinates CRKL. 10 / 10
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"Overall, we discovered that USP53 deubiquitinates CRKL, encourages tumor development and metastasis, and reduces chemosensitivity in TNBC."
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"To date, the regulatory function of USP53 in EMT has not been made explicit.In this study, we verified that USP53 is a deubiquitinating enzyme for CRKL that directly binds, stabilizes, and deubiquitinates CRKL."
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"In conclusion, USP53 plays an important role in TNBC progression by deubiquitinating CRKL."
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"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."
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"As a deubiquitinase, USP53 may control CRKL by deubiquitinating CRKL."
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"USP53 may regulate the proliferation and metastasis of TNBC by deubiquitinating CRKL."
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"Here, we found that CRKL can be deubiquitinated by USP53."
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"The overexpression of USP53 in TNBC promotes the deubiquitination of CRKL and tumor growth and metastasis in TNBC."
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"In summary, we found that USP53 can deubiquitinate CRKL, thus regulating tumor proliferation, metastasis, and sensitivity to chemotherapy in TNBC (Figure 7m)."
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"Notably, USP53 is the first DUB found to deubiquitinate CRKL."
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