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USP53 increases the amount of CRKL. 2 / 2
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"USP53 knockdown reduced CRKL expression in MDA-MB-231 cells, and USP53 overexpression elevated the expression of CRKL in MDA-MB-468 cells (Figure 4f,g)."

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"Taken together, USP53 promotes the process of EMT in TNBC partly by regulating CRKL protein expression."