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APOE mice activates USP53. 1 / 1
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"To confirm the mediating role of USP53 in the effect of endothelial DKK1 on AS and SMC-derived foam cell formation in vivo, DKK1 /APOE mice were injected with recombinant AAV2 vectors that overexpressed SMCs-specific USP53 (AAV2-SM22α-USP53) or Control vector (AAV2-SM22α-Con) for 4 weeks (Figure 8A)."