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USP53 inhibits ccRCC. 5 / 5
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"BrdU cell proliferation assay was also used to test the proliferative ability of cells, and the proliferation of USP53 overexpression cells was inhibited compared with control (Figure 2G,H).3.3 Knockdown USP53 promotes the growth and proliferation of ccRCC."
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"EDU cell proliferation imaging assay and BrdU cell proliferation assay also showed that the proliferation of ccRCC after USP53 knockdown was promoted compare with shGFP (Figure 3E–H).3.4 Overexpression USP53 inhibits migration and invasion of ccRCC."
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"In summary, USP53 inhibits the p65 and p50 complex by deubiquitinating IκBα, and further inhibits the activity of the NF‐κB pathway.3.7 Knockdown USP53 promotes the growth of ccRCC in vivo ."
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"Moreover, USP53 knockdown promoted the ability of clone formation of ccRCC in vivo."
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"Then, we performed immunohistochemical staining on the tissues of patients with renal clear cell carcinoma and found that the expression of USP53 in tumor tissues was significantly lower than paracancerous tissues (Figure 1F).3.2 Overexpression USP53 inhibits the growth and proliferation of ccRCC."
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