IndraLab

Statements

USP53 decreases the amount of TNFSF11. 3 / 3
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"Usp53 null mice displayed increased serum RANKL levels and Usp53 deficient osteoblasts and bone marrow adipocytes have increased expression of Rankl."
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"Loss of USP53 up-regulates RANKL expression, promotes the cytogenesis and functional activity of osteoclasts, and triggers osteodestructive diseases."
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"It has been found that USP53 deficiency upregulates RANKL expression in osteoblasts and bone marrow adipocytes to support osteoclast production through the VDR-SMAD3 pathway and promotes bone marrow adipogenesis [61]."
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