IndraLab

Statements

CRKL binds USP53. 12 / 12
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sparser
"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."
37894400
sparser
"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."
37894400
sparser
"Coimmunoprecipitation analysis showed that endogenous USP53 could bind CRKL ( xref l,m)."
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"Our study shows that USP53 can directly bind, stabilize, and deubiquitinate CRKL and further promote proliferation, migration, invasion, and EMT in TNBC.Recent research has demonstrated that CRKL can control EMT, impacting the development and spread of malignancies."
37894400
sparser
"Taken together, USP53 can directly bind, stabilize, and deubiquitinate CRKL."
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reach
"USP53 Binds, Stabilizes, and Deubiquitinates CRKL."
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reach
"Mechanistically, USP53 directly binds CRKL to stabilize and deubiquitinate it, thereby preventing CRKL degradation."
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reach
"We explored the STRING database to determine the precise mechanism by which USP53 controls EMT and discovered that USP53 can directly bind CRKL (Figure 4a)."
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sparser
"However, further study is needed to determine the sites by which USP53 interacts with CRKL and identify strategies that can be applied to regulate the degree of CRKL deubiquitination by USP53."
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biogrid
No evidence text available
32296183
reach
"Taken together, USP53 can directly bind, stabilize, and deubiquitinate CRKL."
37894400
reach
"Coimmunoprecipitation analysis showed that endogenous USP53 could bind CRKL (Figure 5l,m)."
37894400