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USP53 binds FBXO31. 8 / 10
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"In addition to mediate β‐catenin directly, USP53 binding with FBXO31 further stabilizes β‐catenin in promotion of Wnt/β‐catenin activation in BMSCs and bone regeneration [143]."
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"Mass spectrometry showed that USP53 interacted with F-box only protein 31 (FBXO31) to promote proteasomal degradation of beta-catenin."
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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31DeltaF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."
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"As shown in Fig. xref , USP53 and FBXO31 bound with each other in hBMSCs."
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"To examine whether USP53 interacted with FBXO31 in hBMSCs, co-IP and western blotting were performed using wild-type and mutant FBXO31 (myc-FBXO31ΔF), the latter of which harbored a deletion of the F-box domain, which mediates binding to Skp1 and Cul1."
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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt and beta-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."
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"In addition to mediate β‐catenin directly, USP53 binding with FBXO31 further stabilizes β‐catenin in promotion of Wnt/β‐catenin activation in BMSCs and bone regeneration [ xref ]."
40170748
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"Additionally, we confirmed that USP53 overexpression promoted osteogenesis in hBMSCs by activating the Wnt/β-catenin signaling pathway in vitro and that USP53 bound with FBXO31 during the osteogenic differentiation of hBMSCs."
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