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USP53 inhibits metabolic process. 2 / 2
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2
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"USP53 gene has been associated with some models of tumorigenesis:–In clear cell renal cell carcinoma inhibits the occurrence and development of cancer through NF-κB pathway inactivation [93];–In cervical squamous cell carcinoma correlated with the sensitivity to radiotherapy [94];–In oesophagal carcinoma, USP53 suppresses cancer progression by regulating cell growth and metabolism [95];–In lung adenocarcinoma, USP53 regulates cell apoptosis and glycolysis through the AKT1 pathway acting as a tumour suppressor [96]."