IndraLab

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USP53 binds SR-A. 5 / 5
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"To explore whether USP53 interacts with SR-A, co-immunoprecipitation (Co-IP) and immunoblotting (IB) experiments were performed using HASMCs or HEK293T. The results showed that USP53 and SR-A efficiently co-immunoprecipitated (Figure xref E, 7F)."
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"These results demonstrate that USP53 interacts with SR-A, which can be enhanced by endothelial DKK1."
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"Furthermore, Co-IP experiments confirmed endogenous and exogenous interactions between USP53 and SR-A. These results suggest that USP53 may represent an intermediate molecular mechanism that mediates DKK1 to regulate the expression of SR-A in SMCs and influence the formation of foam cells."
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"Additionally, the interaction between USP53 and SR-A in HASMCs was enhanced by exogenous rDKK1 treatment (Figure xref G) or co-culturing with ECs overexpressing DKK1 (Lenti-GFP-DKK1 EC, Figure xref H)."
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"USP53 interacts with SR-A and regulates K48-linked polyubiquitination in SMCs, which may be enhanced by endothelial DKK1."
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