IndraLab

Statements

TP53 binds USP49. 10 / 13

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"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."

29748582

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sparser

"In our study, we found that USP49 has a positive effect on the transcriptional activity and protein stability of p53 and that USP49 interacts with p53 and suppresses its ubiquitination."

29748582

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reach

"In our study, we found that USP49 has a positive effect on the transcriptional activity and protein stability of p53 and that USP49 interacts with p53 and suppresses its ubiquitination."

29748582

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reach

"USP49 interacts with p53."

29748582

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sparser

"USP49 interacts with p53."

29748582

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"We report that USP49 binds to and stabilizes p53 via deubiquitination."

29748582

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"We therefore performed a co-immunoprecipitation experiment in which Flag-USP49 and HA-p53 plasmids were separately transfected or co-transfected into 293T cells and potential interactions between Flag-USP49 and HA-p53 were examined."

29748582

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sparser

"USP49 binds, deubiquitinates and stabilizes p53 following DNA damage, leading to p53 activation and apoptosis."

32201366

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"We also evaluated interaction between endogenous USP49 and p53 in HCT116 and U2OS cells using a p53 specific antibody."

29748582

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reach

"We next assessed whether USP49 binds to p53."

29748582

GST binds TP53, USP49, and Flag. 1 / 1

| 1

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"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

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29748582

USP49 activates TP53.

| 4

USP49 activates TP53. 4 / 4

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"USP49 upregulates p53 protein stability."

29748582

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"However, knockdown of USP49 by shRNA reduced the level of p53 protein in HCT116 cells treated with or without Eto."

29748582

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reach

"Conversely, overexpression of USP49 suppressed MDM2 gene expression and then promoted TP53 target genes."

35072515

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"To explore the mechanism by which USP49 enhances p53 stability and taking into consideration that USP49 is a member of the USP family of deubiquitinating enzymes, we hypothesized that USP49 may have an effect on p53 ubiquitination."

29748582

USP49 deubiquitinates TP53.

| 3

USP49 leads to the deubiquitination of TP53. 3 / 3

| 3

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"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."

29748582

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reach

"USP49 suppresses p53 ubiquitination."

29748582

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reach

"To assess this, we co-transfected HA-p53, Myc-ubiquitin, and Flag-USP49 into 293T cells, and found that USP49 suppressed ubiquitination of HA-p53."

29748582

USP49 increases the amount of TP53.

| 2

Modified USP49 increases the amount of TP53. 1 / 1

| 1

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"Overexpression of USP49 downregulated the expression levels of Cyclin D1, and upregulated p53 expression."

31001918

USP49 increases the amount of TP53. 1 / 1

| 1

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"Importantly, USP49 knockout stimulated MDM2 transcriptional level and then inhibited the mRNA levels of TP53 target genes."

35072515

USP49 affects STING1

1 1 | 4 9

USP49 binds STING1.

1 | 2 8

USP49 binds STING1. 10 / 11

1 | 2 8

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"In this study, we demonstrated that USP49 interacted with MITA and deconjugated K63-linked polyubiquitin chains from MITA after HSV-1 infection, thereby downregulating MITA activation and turning down immune responses ( xref )."

30943264

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sparser

"In this context, we observed that USP49-MITA association was induced by HSV-1 infection and the basal expression of type I IFNs or proinflammatory cytokines was comparable between the wild-type and Usp49 -/- cells."

30943264

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sparser

"These data together suggest that USP49 interacts with MITA and inhibits MITA-mediated signaling."

30943264

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reach

"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."

30943264

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sparser

"To test our hypothesis, we conducted an unbiased screening of MITA-interacting DUBs by cotransfection and immunoprecipitation assays and found that USP49 interacted with MITA [ xref ]."

30943264

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sparser

"In an unbiased screening of MITA-interacting DUBs, we have found that USP49 interacts with MITA [ xref ]."

30943264

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sparser

"Whether and how the USP49-MITA axis regulates inflammatory diseases such as colitis and tumorigenesis such as colon cancer is of great interest and requires future investigations."

30943264

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"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."

35033428

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sparser

"USP49 interacts with MITA and inhibits MITA-mediated signaling."

30943264

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sparser

"Furthermore, USP49 binds to and deubiquitinates MITA, thus reducing antiviral responses after HSV-1 infection [ xref ]."

35279684

USP49 deubiquitinates STING1.

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USP49 deubiquitinates STING1. 3 / 3

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ubibrowser

"Mechanistically, USP49 removes K63-linked ubiquitin chains from MITA after HSV-1 infection which inhibits the aggregation of MITA and the subsequent recruitment of TBK1 to the signaling complex."

30943264

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reach

"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."

35033428

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reach

"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."

30943264

USP49 ubiquitinates STING1.

| 1

USP49 ubiquitinates STING1. 1 / 1

| 1

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sparser

"Furthermore, we found that reconstitution of USP49 but not USP49 (C262A) into Usp49 -/- MLFs inhibited HSV-1-induced K63-linked ubiquitination of MITA ( xref )."

30943264

TP53 affects USP49

| 6 9

TP53 binds USP49. 10 / 13

| 6 7

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sparser

"Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination."

29748582

➶

sparser

"In our study, we found that USP49 has a positive effect on the transcriptional activity and protein stability of p53 and that USP49 interacts with p53 and suppresses its ubiquitination."

29748582

➶

reach

"In our study, we found that USP49 has a positive effect on the transcriptional activity and protein stability of p53 and that USP49 interacts with p53 and suppresses its ubiquitination."

29748582

➶

reach

"USP49 interacts with p53."

29748582

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sparser

"USP49 interacts with p53."

29748582

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reach

"We report that USP49 binds to and stabilizes p53 via deubiquitination."

29748582

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reach

29748582

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sparser

"USP49 binds, deubiquitinates and stabilizes p53 following DNA damage, leading to p53 activation and apoptosis."

32201366

➶

reach

"We also evaluated interaction between endogenous USP49 and p53 in HCT116 and U2OS cells using a p53 specific antibody."

29748582

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reach

"We next assessed whether USP49 binds to p53."

29748582

GST binds TP53, USP49, and Flag. 1 / 1

| 1

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sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

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sparser

29748582

STING1 affects USP49

1 | 2 8

USP49 binds STING1. 10 / 11

1 | 2 8

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sparser

30943264

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sparser

30943264

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sparser

"These data together suggest that USP49 interacts with MITA and inhibits MITA-mediated signaling."

30943264

➶

reach

"Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses."

30943264

➶

sparser

"To test our hypothesis, we conducted an unbiased screening of MITA-interacting DUBs by cotransfection and immunoprecipitation assays and found that USP49 interacted with MITA [ xref ]."

30943264

➶

sparser

"In an unbiased screening of MITA-interacting DUBs, we have found that USP49 interacts with MITA [ xref ]."

30943264

➶

sparser

"Whether and how the USP49-MITA axis regulates inflammatory diseases such as colitis and tumorigenesis such as colon cancer is of great interest and requires future investigations."

30943264

➶

reach

"USP49, a ubiquitin-specific protease, interacts with and deubiquitinates STING after HSV-1 infection."

35033428

➶

sparser

"USP49 interacts with MITA and inhibits MITA-mediated signaling."

30943264

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sparser

"Furthermore, USP49 binds to and deubiquitinates MITA, thus reducing antiviral responses after HSV-1 infection [ xref ]."

35279684

USP49 is modified

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USP49 is ubiquitinated.

| 8

USP49 is ubiquitinated. 8 / 8

| 8

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sparser

"Furthermore, we found that reconstitution of USP49 but not USP49 (C262A) into Usp49 -/- MLFs inhibited HSV-1-induced K63-linked ubiquitination of MITA ( xref )."

30943264

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sparser

"Moreover, ubiquitination of USP49 was dramatically inhibited in USP49 del but not in WT (Fig. xref and Supplementary Fig. xref )."

35279684

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sparser

"These results indicated that NEK6 has a potential role in the promotion of Fbxo45-mediated ubiquitination and degradation of USP49."

35279684

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"Furthermore, Fbxo45 exerted its oncogenic function partly via promotion of USP49 ubiquitination and degradation."

35279684

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"Furthermore, deletion of SPRY abrogated the ubiquitination of USP49 compared with the F-box deletion and WT of Fbxo45 in Panc-1 cells and 293 T cells (Fig. xref , Supplementary Fig. xref )."

35279684

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sparser

"We observed that Fbxo45 could bind to specific degrons of USP49 through its SPRY domain and enhance USP49 ubiquitination, subsequently leading to USP49 protein destruction in a posttranslational manner."

35279684

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sparser

"Furthermore, our results also demonstrated that Fbxo45 promoted USP49 ubiquitination (Fig. xref and Supplementary Fig. xref )."

35279684

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sparser

"More importantly, NEK6 strengthened the Fbxo45-mediated ubiquitination of USP49 WT, while NEK6 had no influence on the ubiquitination of USP49 del (Fig. xref and Supplementary Fig. xref )."

35279684

USP49 is phosphorylated.

| 2

USP49 is phosphorylated. 2 / 2

| 2

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"Some NEKs, including NEK1, NEK2, NEK4, and NEK5, were observed to be involved in USP49 Ser/Thr residue phosphorylation by the Scansite program."

35279684

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sparser

"To identify specific kinase(s) required for USP49 degradation, we used the Scansite program to predict the proper kinase(s) responsible for phosphorylation of USP49."

35279684

USP49 affects APOBEC3G

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USP49 activates APOBEC3G.

| 6

USP49 activates APOBEC3G. 6 / 6

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eidos

"USP49 enhances the expression of A3G even in absence of Vif ."

31397674

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eidos

"This result verifies that the inhibition of USP49 can promote the degradation of A3G and subsequently reduce the hypermutation in virus.These data indicated that the anti-A3G effect of Vif can be enforced by depletion of the A3G protein stabilizer USP49 , alternatively supporting the fact that USP49 enhances the anti-HIV-1 effect of A3G ."

31397674

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eidos

"USP49 enhanced A3G levels in both cell lysates and viral particles ( Figure 3D ) ."

31397674

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eidos

"This result verifies that the inhibition of USP49 can promote the degradation of A3G and subsequently reduce the hypermutation in virus ."

31397674

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eidos

"USP49 directly interacts with A3G and deubiquitinates the K48-linked ubiquitination of A3G mediated by vif Considering that USP49 could enhance the expression of A3G directly , we next assessed whether USP49 binds A3G ."

31397674

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eidos

"USP49 enhances the expression of A3G even in the absence of HIV-1 vif Unexpectedly , in the absence of Vif , USP49 knockdown with siRNA also significantly decreased A3G stability , which could be rescued by MG132 ( Figure 3A , B ) , suggesting that A3G could be degraded through a Vif-independent pathway ."

31397674

USP49 inhibits APOBEC3G.

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USP49 inhibits APOBEC3G. 2 / 2

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eidos

"It is stated that USP49 significantly suppressed downregulation of A3G at moderate levels of Vif , but the effect was limited at high levels of Vif ."

31397674

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eidos

"USP49 interacted with and removes ubiquitins from A3G , and thereby prevents the degradation of A3G ."

31397674

Valproic acid affects USP49

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Valproic acid decreases the amount of USP49.

6 |

Valproic acid decreases the amount of USP49. 6 / 6

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ctd

No evidence text available

27188386

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ctd

No evidence text available

24935251

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ctd

No evidence text available

28001369

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ctd

No evidence text available

23179753

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ctd

No evidence text available

26272509

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ctd

No evidence text available

24383497

Valproic acid increases the amount of USP49.

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Valproic acid increases the amount of USP49. 1 / 1

1 |

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ctd

No evidence text available

17183730

USP49 affects cell population proliferation

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USP49 inhibits cell population proliferation.

| 4 1

USP49 inhibits cell population proliferation. 5 / 5

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"USP49 knockout contributes to increased HCT116 cell proliferation and migration."

35072515

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"As shown in Fig. 6D, overexpression of USP49 significantly inhibited cell proliferation and reversed the promotion effect of miR-5000-3p on cell proliferation ability.Due to USP49 was involved in the PI3K/AKT signaling pathway ."

34075026

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sparser

"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."

28363942

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"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."

28363942

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"A previous study suggested depletion of USP49 increased pancreatic cancer cell proliferation in vitro, tumorigenesis in vivo, and chemoresistance, proposing that USP49 regulates tumorigenesis and chemoresistance in pancreatic cancer in an AKT-dependent manner ."

34075026

USP49 activates cell population proliferation.

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USP49 activates cell population proliferation. 2 / 2

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"In this study, ubiquitin-specific peptidase 49 (USP49) was identified as a novel deubiquitinase of YAP1, knockdown of USP49 inhibited the proliferation, metastasis, chemoresistance, and peritoneal metastasis of GC cells."

35318441

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"We show that loss of USP49 in different cancer cell lines impairs proliferation and increases aneuploidy."

36702832

USP49 affects Histone_H2B

| 7

USP49 deubiquitinates Histone_H2B.

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USP49 deubiquitinates Histone_H2B. 6 / 6

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"It has been reported that USP49 deubiquitinates histone H2B and regulates co-transcriptional pre-mRNA splicing; interestingly, p53 is also mainly localized to the nucleus."

29748582

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"Silencing Usp49 induces relatively small changes in gene expression, however alterations in H2B ubiquitination levels caused by Usp49 regulate U1A and U2B association with chromatin and binding to nascent pre-mRNA."

25962961

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"Usp49 in complex with RVB1 and SUG1 yeast homologues deubiquitinates H2B, this modification is required for efficient co-transcriptional splicing of a large set of exons."

25962961

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"Here we report the purification of ubiquitin specific peptidase 49 (USP49) as a histone H2B specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons."

23824326

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"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."

23824326

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reach

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

USP49 decreases the amount of Histone_H2B.

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USP49 decreases the amount of Histone_H2B. 1 / 1

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25962961

USP49 affects RUVBL1

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RUVBL1 binds USP49. 3 / 4

2 | 1

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biogrid

No evidence text available

23824326

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reach

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

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biogrid

No evidence text available

23824326

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

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sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

USP49 affects PSMC5

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USP49 binds PSMC5. 3 / 4

2 | 1

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biogrid

No evidence text available

23824326

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biogrid

No evidence text available

23824326

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reach

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

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sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

USP49 affects PI3K

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USP49 inhibits PI3K.

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USP49 inhibits PI3K. 4 / 4

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"USP49 was also reported to inhibit non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling ."

34075026

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reach

34075026

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reach

"In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling."

31001918

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reach

"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."

31001918

USP49 activates PI3K.

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USP49 activates PI3K. 1 / 1

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"In conclusion, we demonstrated that USP49 was functional in NSCLC cells, and inhibited NSCLC cell growth by suppressing PI3K and AKT signaling, suggesting that USP49 could be as a novel target for NSCLC therapy."

31001918

USP49 affects PAX9

| 5

USP49 deubiquitinates PAX9.

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USP49 deubiquitinates PAX9. 2 / 2

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"We identify and demonstrate that USP49 interacts with and deubiquitinates PAX9 and MSX1, thereby extending their protein half-lives."

35273362

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reach

"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."

35273362

USP49 increases the amount of PAX9.

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USP49 increases the amount of PAX9. 1 / 1

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"On the other hand, the loss of USP49 reduces the levels of PAX9 and MSX1 proteins, which causes transient retardation of odontogenic differentiation in human dental pulp stem cells and delays the differentiation of human pluripotent stem cells into the neural crest cell lineage."

35273362

USP49 decreases the amount of PAX9.

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USP49 decreases the amount of PAX9. 1 / 1

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35273362

USP49 binds PAX9.

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USP49 binds PAX9. 1 / 1

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"We identify and demonstrate that USP49 interacts with and deubiquitinates PAX9 and MSX1, thereby extending their protein half-lives."

35273362

RUVBL1 affects USP49

2 | 1 1

RUVBL1 binds USP49. 3 / 4

2 | 1

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biogrid

No evidence text available

23824326

➶

reach

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

➶

biogrid

No evidence text available

23824326

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

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sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

PSMC5 affects USP49

2 | 1 1

USP49 binds PSMC5. 3 / 4

2 | 1

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biogrid

No evidence text available

23824326

➶

biogrid

No evidence text available

23824326

➶

reach

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

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sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

USP49 affects DUSP1

1 | 2 1

USP49 binds DUSP1.

| 1 1

USP49 binds DUSP1. 2 / 2

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"The direct interaction between USP49 and DUSP1 was measured by coimmunoprecipitation and ubiquitination analysis."

30246457

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sparser

"The direct interaction between USP49 and DUSP1 was measured by coimmunoprecipitation and ubiquitination analysis."

30246457

USP49 increases the amount of DUSP1.

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USP49 increases the amount of DUSP1. 1 / 1

| 1

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"Moreover, USP49 positively regulated DUSP1 expression through deubiquitinating DUSP1."

30246457

USP49 deubiquitinates DUSP1.

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USP49 deubiquitinates DUSP1. 1 / 1

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ubibrowser

"Moreover, USP49 positively regulated DUSP1 expression through deubiquitinating DUSP1."

30246457

USP49 affects AKT

| 4

USP49 inhibits AKT.

| 3

USP49 inhibits AKT. 3 / 3

| 3

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reach

"In contrast, another DUB, USP49, inhibits AKT pathway by promoting interaction of PHLPP1 to AKT, thus facilitating the de-phosphorylation of AKT."

28923280

➶

reach

"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."

31001918

➶

reach

"In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling."

31001918

USP49 activates AKT.

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USP49 activates AKT. 1 / 1

| 1

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reach

31001918

TFDP1 affects USP49

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TFDP1 decreases the amount of USP49. 4 / 4

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

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biopax:msigdb

No evidence text available

FBXO45 affects USP49

| 4

FBXO45 ubiquitinates USP49.

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FBXO45 ubiquitinates USP49. 2 / 2

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sparser

"Furthermore, our results also demonstrated that Fbxo45 promoted USP49 ubiquitination (Fig. xref and Supplementary Fig. xref )."

35279684

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sparser

"Fbxo45-induced USP49 ubiquitination and degradation depend on its SPRY domain."

35279684

FBXO45 binds USP49.

| 2

USP49 binds FBXO45. 2 / 2

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sparser

"More importantly, compared with WT, USP49 del significantly reduced the USP49 interaction with Fbxo45 (Fig. xref and Supplementary Fig. xref )."

35279684

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sparser

"Moreover, coIP assays showed that Fbxo45 specifically interacted with USP49 in Panc-1 cells and 293 T cells (Fig. xref and Supplementary Fig. S xref )."

35279684

Trichostatin A affects USP49

3 |

Trichostatin A decreases the amount of USP49. 3 / 3

3 |

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ctd

No evidence text available

24935251

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

26272509

Bisphenol A affects USP49

3 |

Bisphenol A methylates USP49.

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Bisphenol A methylates USP49. 1 / 1

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ctd

No evidence text available

30906313

Bisphenol A increases the amount of USP49.

1 |

Bisphenol A increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

30248606

Bisphenol A decreases the amount of USP49.

1 |

Bisphenol A decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

25181051

USP49 affects miR-5000-3p

| 1 2

USP49 increases the amount of miR-5000-3p.

| 1

USP49 bound to miR-5000-3p promoter increases the amount of miR-5000-3p. 1 / 1

| 1

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"Molecular mechanism assays revealed that USP49 binds to the miR-5000-3p promoter to increase the expression of miR-5000-3p, resulting in cancer cells sensitized to OXA."

34075026

USP49 decreases the amount of miR-5000-3p.

| 1

USP49 decreases the amount of miR-5000-3p. 1 / 1

| 1

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reach

"USP49 suppresses miR-5000-3p expression and regulates PI3K/AKT signal pathway."

34075026

USP49 activates miR-5000-3p.

| 1

USP49 activates miR-5000-3p. 1 / 1

| 1

➶

eidos

"Molecular mechanism assays revealed that USP49 binds to the miR-5000-3p promoter to increase the expression of miR-5000-3p , resulting in cancer cells sensitized to OXA ."

34075026

USP49 affects gemcitabine

| 3

USP49 activates gemcitabine.

| 2

USP49 activates gemcitabine. 2 / 2

| 2

➶

reach

"Luo et al. [XREF_BIBR] found that FKBP51 could promote PHLPP-Akt interaction and following Akt dephosphorylation at ser473, so that USP49 enhanced cellular response to gemcitabine through FKBP51-Akt signaling."

28938696

➶

reach

"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."

28363942

USP49 deubiquitinates gemcitabine.

| 1

USP49 deubiquitinates gemcitabine. 1 / 1

| 1

➶

reach

"Recent studies show that DUBs play essential roles in proliferation, motility, and chemoresistance of malignant cells through stabilizing critical proteins.5 For example, USP49 deubiquitinates FKBP51, which serves as a scaffold for dephosphorylating Ser473 residue at Akt, and further sensitizes pancreatic cancer cells to gemcitabine."

30296012

USP49 affects cell growth

| 3

USP49 inhibits cell growth. 3 / 3

| 3

➶

reach

"As a result, overexpression of USP49 significantly inhibited cell growth of NSCLC cells."

31001918

➶

reach

"USP49 was also reported to inhibit non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling ."

34075026

➶

reach

31001918

USP49 affects Neoplasms

| 1 2

USP49 activates Neoplasms.

| 1 1

USP49 activates Neoplasms. 2 / 2

| 1 1

➶

eidos

"USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer ."

35318441

➶

reach

"USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer."

35318441

USP49 inhibits Neoplasms.

| 1

USP49 inhibits Neoplasms. 1 / 1

| 1

➶

reach

"Xenograft mouse experiments demonstrated that ectopic expression of Fbxo45 enhanced tumor growth in mice and that USP49 overexpression inhibited tumor growth in vivo."

35279684

USP49 affects MSX1

| 3

USP49 increases the amount of MSX1.

| 1

USP49 increases the amount of MSX1. 1 / 1

| 1

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reach

35273362

USP49 deubiquitinates MSX1.

| 1

USP49 deubiquitinates MSX1. 1 / 1

| 1

➶

reach

"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."

35273362

USP49 decreases the amount of MSX1.

| 1

USP49 decreases the amount of MSX1. 1 / 1

| 1

➶

reach

35273362

USP49 affects MDM2

| 2 1

USP49 decreases the amount of MDM2.

| 2

USP49 decreases the amount of MDM2. 2 / 2

| 2

➶

reach

"Importantly, USP49 knockout stimulated MDM2 transcriptional level and then inhibited the mRNA levels of TP53 target genes."

35072515

➶

reach

"Conversely, overexpression of USP49 suppressed MDM2 gene expression and then promoted TP53 target genes."

35072515

USP49 binds MDM2.

| 1

USP49 binds MDM2. 1 / 1

| 1

➶

sparser

"Moreover, chromatin immunoprecipitation revealed that USP49 directly bound to the promoter of MDM2 gene."

35072515

USP49 affects HIV-1 infectivity

| 3

USP49 inhibits HIV-1 infectivity. 3 / 3

| 3

➶

eidos

"Essential revisions : 1 ) The authors should provide more solid and systematic data to show that USP49 inhibits HIV-1 infectivity through A3G ."

31397674

➶

eidos

"Results in the new Figure 2E showed that USP49 worked with endogenous A3G to inhibit HIV-1 infectivity ."

31397674

➶

eidos

"3 ) The authors should show that USP49 works with the endogenous A3G to inhibit HIV-1 infectivity ."

31397674

USP49 affects H2BC21

1 2 |

USP49 deubiquitinates H2BC21.

2 |

USP49 deubiquitinates H2BC21. 2 / 2

2 |

➶

ubibrowser

No evidence text available

➶

ubibrowser

"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing."

23824326

USP49 binds H2BC21.

1 |

USP49 binds H2BC21. 1 / 1

1 |

➶

biogrid

No evidence text available

23824326

USP49 affects FKBP4

1 | 2

USP49 deubiquitinates FKBP4. 3 / 3

1 | 2

➶

ubibrowser

"Here we report that a deubiquitinase, USP49, is a new regulator of the AKT pathway.| Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."

28363942

➶

reach

"Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner."

28363942

➶

reach

30296012

USP49 affects Cell Survival

| 3

USP49 activates Cell Survival.

| 2

USP49 activates Cell Survival. 2 / 2

| 2

➶

reach

"USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling."

30246457

➶

reach

"This study identified a novel mechanism by which USP49 promotes CRC cell survival by stabilizing BAG2 through the c-MYC-USP49-BAG2 axis, indicating that USP49 may become a potential therapeutic target for CRC."

35367823

USP49 inhibits Cell Survival.

| 1

USP49 inhibits Cell Survival. 1 / 1

| 1

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reach

"Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes."

30246457

Vorinostat affects USP49

2 |

Vorinostat decreases the amount of USP49. 2 / 2

2 |

➶

ctd

No evidence text available

26272509

➶

ctd

No evidence text available

27188386

Pirinixic acid affects USP49

2 |

Pirinixic acid decreases the amount of USP49.

1 |

Pirinixic acid decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

19710929

Pirinixic acid activates USP49.

1 |

Pirinixic acid activates USP49. 1 / 1

1 |

➶

ctd

No evidence text available

19710929

Phenylmercury acetate affects USP49

2 |

Phenylmercury acetate decreases the amount of USP49. 2 / 2

2 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

26272509

Panobinostat affects USP49

2 |

Panobinostat decreases the amount of USP49. 2 / 2

2 |

➶

ctd

No evidence text available

27188386

➶

ctd

No evidence text available

26272509

MiR-5000-3p affects USP49

| 2

MiR-5000-3p inhibits USP49.

| 1

MiR-5000-3p inhibits USP49. 1 / 1

| 1

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reach

"The qRT-PCR data show that the expression of miR-5000-3p decreased in OR-HCT116 cells expressing high USP49 compared with that in control and OE-NC cells (Fig. 6C)."

34075026

MiR-5000-3p decreases the amount of USP49.

| 1

MiR-5000-3p decreases the amount of USP49. 1 / 1

| 1

➶

reach

"As presented in Fig. 6A, the overexpression of miR-5000-3p reduced USP49 level in HCT116 cells while knockdown of miR-5000-3p elevated USP49 expression in OR-CRC cells, respectively."

34075026

Bis(2-ethylhexyl) phthalate affects USP49

| 2

Bis(2-ethylhexyl) phthalate activates USP49. 2 / 2

| 2

➶

eidos

"These findings suggest that USP49 upregulation by DEHP induces cell death via p53 regulation , which subsequently leads to POF due to follicle depletion ."

32143396

➶

eidos

"Multiplex RT-PCR and Western blot analysis revealed that USP49 was upregulated by DEHP in A2780 and OVCAR5 cells ."

32143396

USP49 affects signaling

| 2

USP49 inhibits signaling. 2 / 2

| 2

➶

sparser

"In mechanism, overexpression of USP49 inhibited PI3K/AKT signaling, but knockdown of USP49 enhanced this signaling."

31001918

➶

sparser

"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K/AKT signaling by stabilizing PTEN in NSCLC cells."

31001918

USP49 affects protein kinase B signaling

| 2

USP49 inhibits protein kinase B signaling. 2 / 2

| 2

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reach

"USP49 was also reported to inhibit non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling ."

34075026

➶

reach

34075026

USP49 affects apoptotic process

| 2

USP49 inhibits apoptotic process.

| 1

USP49 inhibits apoptotic process. 1 / 1

| 1

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reach

"USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling."

30246457

USP49 activates apoptotic process.

| 1

USP49 activates apoptotic process. 1 / 1

| 1

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reach

"Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes."

30246457

USP49 affects USP44

1 | 1

USP44 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

USP49 affects PTEN

| 2

USP49 inhibits PTEN.

| 1

USP49 inhibits PTEN. 1 / 1

| 1

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reach

"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."

31001918

USP49 deubiquitinates PTEN.

| 1

USP49 deubiquitinates PTEN. 1 / 1

| 1

➶

reach

"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."

31001918

USP49 affects Osteoarthritis

| 1 1

USP49 inhibits Osteoarthritis. 2 / 2

| 1 1

➶

eidos

"USP49 attenuates OA progression by inhibiting the Wnt / beta-catenin pathway ."

34216299

➶

reach

"USP49 attenuates OA progression by inhibiting the Wnt/β-catenin pathway."

34216299

USP49 affects MDM2-p53 axis genes

| 2

USP49 increases the amount of MDM2-p53 axis genes.

| 1

USP49 increases the amount of MDM2-p53 axis genes. 1 / 1

| 1

➶

reach

"Therefore, our findings indicated that USP49-mediated H2B deubiquitination controls the transcription of MDM2-p53 axis genes in the process of HCT116 cell proliferation."

35072515

USP49 deubiquitinates MDM2-p53 axis genes.

| 1

USP49 leads to the deubiquitination of MDM2-p53 axis genes. 1 / 1

| 1

➶

reach

"Therefore, our findings indicated that USP49-mediated H2B deubiquitination controls the transcription of MDM2-p53 axis genes in the process of HCT116 cell proliferation."

35072515

USP49 affects Flag

| 2

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

USP49 affects FKBP5

1 1 |

USP49 deubiquitinates FKBP5.

1 |

USP49 deubiquitinates FKBP5. 1 / 1

1 |

➶

ubibrowser

28363942

USP49 binds FKBP5.

1 |

USP49 binds FKBP5. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects FBXO45

| 2

USP49 binds FBXO45. 2 / 2

| 2

➶

sparser

"More importantly, compared with WT, USP49 del significantly reduced the USP49 interaction with Fbxo45 (Fig. xref and Supplementary Fig. xref )."

35279684

➶

sparser

"Moreover, coIP assays showed that Fbxo45 specifically interacted with USP49 in Panc-1 cells and 293 T cells (Fig. xref and Supplementary Fig. S xref )."

35279684

USP49 affects BBC3

| 2

Modified USP49 increases the amount of BBC3. 1 / 1

| 1

➶

reach

"Overexpression of USP49 significantly increased p21, BAX, and PUMA mRNA levels, whereas knockdown of USP49 suppressed p21, BAX, and PUMA levels when HCT116 cells were exposed to Eto."

29748582

USP49 increases the amount of BBC3. 1 / 1

| 1

➶

reach

"Overexpression of USP49 significantly increased p21, BAX, and PUMA mRNA levels, whereas knockdown of USP49 suppressed p21, BAX, and PUMA levels when HCT116 cells were exposed to Eto."

29748582

USP49 affects BAG2

| 2

USP49 deubiquitinates BAG2.

| 1

USP49 deubiquitinates BAG2. 1 / 1

| 1

➶

reach

"Investigation of mechanisms unravels that USP49 deubiquitinates and stabilizes Bcl-2-Associated Athanogene 2 (BAG2), a well-known protein that antagonizes apoptosis and enables adaptive response of CRC cells."

35367823

USP49 activates BAG2.

| 1

USP49 activates BAG2. 1 / 1

| 1

➶

reach

35367823

USP49 affects Aneuploidy

| 2

USP49 inhibits Aneuploidy.

| 1

USP49 inhibits Aneuploidy. 1 / 1

| 1

➶

reach

"USP49 deubiquitinase regulates the mitotic spindle checkpoint and prevents aneuploidy."

36702832

USP49 activates Aneuploidy.

| 1

USP49 activates Aneuploidy. 1 / 1

| 1

➶

reach

"We show that loss of USP49 in different cancer cell lines impairs proliferation and increases aneuploidy."

36702832

USP49 affects AXIN

| 2

Modified USP49 leads to the ubiquitination of AXIN. 1 / 1

| 1

➶

reach

"Treating primary rat chondrocytes with different concentrations of IL-1beta resulted in decreased Usp49 expression, while Usp49 overexpression could attenuate IL-1beta-induced chondrocyte apoptosis by promoting Axin deubiquitination."

32737772

USP49 leads to the ubiquitination of AXIN. 1 / 1

| 1

➶

reach

"USP49 is lowly expressed in human OA chondrocytes and overexpression of USP49 in primary rat chondrocytes inhibits apoptosis by promoting AXIN deubiquitination and reducing the level of IL-1β, a marker for OA progression (Fig. 1) [26]."

34216299

USP44 affects USP49

1 | 1

USP44 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

TP53 affects Flag

| 2

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

NEK6 affects USP49

| 1 1

NEK6 ubiquitinates USP49.

| 1

NEK6 leads to the ubiquitination of USP49. 1 / 1

| 1

➶

reach

"Furthermore, Fbxo45-mediated USP49 ubiquitination and degradation are enhanced by NEK6 kinase."

35279684

NEK6 binds USP49.

| 1

USP49 binds NEK6. 1 / 1

| 1

➶

sparser

"However, we found that NEK6 specifically interacted with USP49 but not NEK3, suggesting that NEK6 was critically involved in USP49 degradation (Supplementary Fig. xref )."

35279684

MYC affects USP49

| 1 1

MYC activates USP49. 2 / 2

| 1 1

➶

eidos

"Here we revealed that Ubiquitin Specific Peptidase 49 ( USP49 ) is transcriptionally activated by c-MYC in colorectal cancer ( CRC ) , and CRC patients with elevated USP49 levels exhibited significantly shorter survival ."

35367823

➶

reach

"Here we revealed that Ubiquitin Specific Peptidase 49 (USP49) is transcriptionally activated by c-MYC in colorectal cancer (CRC), and CRC patients with elevated USP49 levels exhibited significantly shorter survival."

35367823

LEF1 affects USP49

2 |

LEF1 decreases the amount of USP49. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

GTF3A affects USP49

2 |

GTF3A decreases the amount of USP49. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

Flag affects USP49

| 2

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

E2F1 affects USP49

2 |

E2F1 decreases the amount of USP49. 2 / 2

2 |

➶

biopax:msigdb

No evidence text available

➶

biopax:msigdb

No evidence text available

DUSP1 affects USP49

| 1 1

USP49 binds DUSP1. 2 / 2

| 1 1

➶

reach

"The direct interaction between USP49 and DUSP1 was measured by coimmunoprecipitation and ubiquitination analysis."

30246457

➶

sparser

"The direct interaction between USP49 and DUSP1 was measured by coimmunoprecipitation and ubiquitination analysis."

30246457

6-propyl-2-thiouracil affects USP49

2 |

6-propyl-2-thiouracil decreases the amount of USP49. 2 / 2

2 |

➶

ctd

No evidence text available

25825206

➶

ctd

No evidence text available

24780913

Tris(1,3-dichloro-2-propyl)phosphate affects USP49

1 |

Tris(1,3-dichloro-2-propyl)phosphate decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

30157643

Torcetrapib affects USP49

1 |

Torcetrapib increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

23228038

Thimerosal affects USP49

1 |

Thimerosal decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Tetrachloromethane affects USP49

1 |

Tetrachloromethane decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Sunitinib affects USP49

1 |

Sunitinib decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

31533062

Silicon dioxide affects USP49

1 |

Silicon dioxide increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

23806026

Schizandrin B affects USP49

1 |

Schizandrin B decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

31150632

Progesterone affects USP49

1 |

Progesterone decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

19690047

Pentanal affects USP49

1 |

Pentanal decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

26079696

MiR-5000-3p promoter affects USP49

| 1

USP49 binds miR-5000-3p promoter. 1 / 1

| 1

➶

reach

"Molecular mechanism assays revealed that USP49 binds to the miR-5000-3p promoter to increase the expression of miR-5000-3p, resulting in cancer cells sensitized to OXA."

34075026

Methylmercury chloride affects USP49

1 |

Methylmercury chloride decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

28001369

Methyl methanesulfonate affects USP49

1 |

Methyl methanesulfonate increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Hydralazine affects USP49

1 |

Hydralazine increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

17183730

Hsa-miR-939-3p affects USP49

1 |

Hsa-miR-939-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6890-3p affects USP49

1 |

Hsa-miR-6890-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6852-5p affects USP49

1 |

Hsa-miR-6852-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6836-3p affects USP49

1 |

Hsa-miR-6836-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6829-3p affects USP49

1 |

Hsa-miR-6829-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6791-3p affects USP49

1 |

Hsa-miR-6791-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6783-3p affects USP49

1 |

Hsa-miR-6783-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6778-3p affects USP49

1 |

Hsa-miR-6778-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6756-3p affects USP49

1 |

Hsa-miR-6756-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6742-3p affects USP49

1 |

Hsa-miR-6742-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6741-3p affects USP49

1 |

Hsa-miR-6741-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-6738-3p affects USP49

1 |

Hsa-miR-6738-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-5088-3p affects USP49

1 |

Hsa-miR-5088-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-5001-3p affects USP49

1 |

Hsa-miR-5001-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4749-3p affects USP49

1 |

Hsa-miR-4749-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4727-5p affects USP49

1 |

Hsa-miR-4727-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4638-5p affects USP49

1 |

Hsa-miR-4638-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-4284 affects USP49

1 |

Hsa-miR-4284 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-324-3p affects USP49

1 |

Hsa-miR-324-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-3127-3p affects USP49

1 |

Hsa-miR-3127-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-23b-5p affects USP49

1 |

Hsa-miR-23b-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-23a-5p affects USP49

1 |

Hsa-miR-23a-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-210-5p affects USP49

1 |

Hsa-miR-210-5p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1913 affects USP49

1 |

Hsa-miR-1913 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1343-3p affects USP49

1 |

Hsa-miR-1343-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1307-3p affects USP49

1 |

Hsa-miR-1307-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Hsa-miR-1237-3p affects USP49

1 |

Hsa-miR-1237-3p decreases the amount of USP49. 1 / 1

1 |

➶

biopax:mirtarbase

No evidence text available

23824327

Formaldehyde affects USP49

1 |

Formaldehyde increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Ethyl methanesulfonate affects USP49

1 |

Ethyl methanesulfonate increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

23649840

Entinostat affects USP49

1 |

Entinostat decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

26272509

Endosulfan affects USP49

1 |

Endosulfan increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

29391264

Dorsomorphin affects USP49

1 |

Dorsomorphin decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

27188386

Cycloheximide affects USP49

| 1

Cycloheximide activates USP49. 1 / 1

| 1

➶

reach

"To this end, HCT116 cells stably transfected with or without Flag-USP49 were treated with 50mug/ml cycloheximide (CHX) for various time points, and the results showed a longer half-life of the p53 protein in cells overexpressing USP49."

29748582

Copper atom affects USP49

1 |

Copper atom increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

20971185

All-trans-retinoic acid affects USP49

1 |

All-trans-retinoic acid decreases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

21934132

Abrine affects USP49

1 |

Abrine increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

31054353

[6]-gingerol affects USP49

| 1

[6]-gingerol increases the amount of USP49. 1 / 1

| 1

➶

reach

"Interestingly, we also found that [6]-gingerol, an anti-OA drug, could upregulate the protein level of Usp49 and suppress the Wnt and beta-catenin signaling cascade in primary rat chondrocytes."

32737772

ZIC1 affects USP49

1 |

ZIC1 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

YARS2 affects USP49

1 |

USP49 binds YARS2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

YAP1 affects USP49

| 1

YAP1 bound to TEAD4 activates USP49. 1 / 1

| 1

➶

reach

"Moreover, USP49 was transcriptionally activated by the YAP1/TEAD4 complex, which formed a positive feedback loop with YAP1 to promote the malignant progression of GC cells."

35318441

VDR affects USP49

1 |

VDR decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

USP7 affects USP49

| 1

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

USP49 affects ubiquitination proteins

| 1

USP49 inhibits ubiquitination proteins. 1 / 1

| 1

➶

eidos

"Recently , it has been shown that USP49 interacts with p53 , dual-specificity protein phosphatases ( DUSP ) , or FKBP51 in the nucleus , and consequently suppresses the ubiquitination of these proteins ( Luo et al ., 2017 ; Tu et al ., 2018 ; Zhang et al ., 2019 ) ."

31397674

USP49 affects type I interferons

| 1

USP49 inhibits type I interferons. 1 / 1

| 1

➶

reach

"Knockdown or knockout of USP49 potentiated HSV-1-, cytoplasmic DNA- or cGAMP induced production of type I interferons (IFNs) and proinflammatory cytokines and impairs HSV-1 replication."

30943264

USP49 affects steady

| 1

USP49 activates steady. 1 / 1

| 1

➶

eidos

"The authors found that a DUB , USP49 , directly interacts with A3G and removes ubiquitins from A3G , increasing its steady state levels and its antiviral activity ."

31397674

USP49 affects several morphological defects

| 1

USP49 inhibits several morphological defects. 1 / 1

| 1

➶

eidos

"USP49 depletion produced several morphological defects during tooth development , such as reduced dentin growth with shrunken enamel space , and abnormal enamel formation including irregular mineralization ."

35273362

USP49 affects rescue virus

| 1

USP49 inhibits rescue virus. 1 / 1

| 1

➶

eidos

"The authors should sequence the proviral DNA in the cultures at the 21-day time point to verify that the rescue in virus was not due to reversion of the Y40H mutation and due to suppression of USP49 ."

31397674

USP49 affects okadaic acid

| 1

USP49 inhibits okadaic acid. 1 / 1

| 1

➶

reach

"Taken together, our study not only demonstrates that Usp49 can negatively regulate the progression of OA by inhibiting the Wnt and beta-catenin signaling cascade, but also elucidates the underlying molecular mechanisms."

32737772

USP49 affects miR-5000-3p promoter

| 1

USP49 binds miR-5000-3p promoter. 1 / 1

| 1

➶

reach

"Molecular mechanism assays revealed that USP49 binds to the miR-5000-3p promoter to increase the expression of miR-5000-3p, resulting in cancer cells sensitized to OXA."

34075026

USP49 affects mgl-1

| 1

USP49 decreases the amount of mgl-1. 1 / 1

| 1

➶

reach

"In contrast, a catalytic mutant USP11 (C266S) and USP49 which were used as negative controls, failed to reduce the ubiquitination level of Mgl-1."

26919101

USP49 affects inhibitory A3G infectivity HIV-1

| 1

USP49 activates inhibitory A3G infectivity HIV-1. 1 / 1

| 1

➶

eidos

"USP49 enhances the inhibitory effect of A3G on the infectivity of HIV-1 ."

31397674

USP49 affects inhibitory A3G HIV-1 infectivity

| 1

USP49 activates inhibitory A3G HIV-1 infectivity. 1 / 1

| 1

➶

eidos

"USP49 enhances the inhibitory effect of A3G on HIV-1 infectivity To evaluate the inhibitory effect of DUB proteins on the Vif-positive HIV-1 replication , we co-transfected 293 T cells with USP49-specific siRNA , pNL4-3DeltaVif , and various amounts of A3G - and Vif-expressing plasmids ."

31397674

USP49 affects hypermutation

| 1

USP49 activates hypermutation. 1 / 1

| 1

➶

eidos

31397674

USP49 affects hypermutation virus

| 1

USP49 activates hypermutation virus. 1 / 1

| 1

➶

eidos

"This result verifies that the inhibition of USP49 can promote the degradation of A3G and subsequently reduce the hypermutation in virus ."

31397674

USP49 affects etoposide

| 1

USP49 activates etoposide. 1 / 1

| 1

➶

reach

"Finally, we found that USP49 can increase cell sensitivity to etoposide (Eto)-induced DNA damage and that USP49-knockout mice are more susceptible to colorectal cancer induced by azoxymethane and dextran sulfate sodium (AOM and DSS)."

29748582

USP49 affects endogenous A3G

| 1

USP49 activates endogenous A3G. 1 / 1

| 1

➶

eidos

"USP49 is expected to aid the endogenous A3G to inhibit HIV-1 infectivity ."

31397674

USP49 affects downregulation of A3G

| 1

USP49 inhibits downregulation of A3G. 1 / 1

| 1

➶

eidos

"The results showed that USP49 significantly suppressed the downregulation of A3G when Vif levels were moderate ."

31397674

USP49 affects defective proviruses latently-infected cells

| 1

USP49 activates defective proviruses latently-infected cells. 1 / 1

| 1

➶

eidos

"Combined with the G to A hypermutation measurements , these data suggest that USP49 contributes to the generation of defective proviruses in the HIV-1 latently-infected cells and therefore the actual size of the viral reservoir ."

31397674

USP49 affects colony chemotherapy resistance

| 1

USP49 activates colony chemotherapy resistance. 1 / 1

| 1

➶

eidos

"Knockdown of USP49 markedly inhibited CRC cell proliferation , colony formation , and chemotherapy resistance in vitro ."

35367823

USP49 affects cell

| 1

USP49 activates cell. 1 / 1

| 1

➶

eidos

"Knockdown of USP49 markedly inhibited CRC cell proliferation , colony formation , and chemotherapy resistance in vitro ."

35367823

USP49 affects cell death

| 1

USP49 activates cell death. 1 / 1

| 1

➶

eidos

"These findings suggest that USP49 upregulation by DEHP induces cell death via p53 regulation , which subsequently leads to POF due to follicle depletion ."

32143396

USP49 affects cell cycle

| 1

USP49 activates cell cycle. 1 / 1

| 1

➶

reach

"Further flow cytometry analysis showed that overexpressed USP49 induced cell cycle arrest at G0/G1 phase."

31001918

USP49 affects antiviral agent

| 1

USP49 activates antiviral agent. 1 / 1

| 1

➶

eidos

"The authors found that a DUB , USP49 , directly interacts with A3G and removes ubiquitins from A3G , increasing its steady state levels and its antiviral activity ."

31397674

USP49 affects anti-HIV-1 A3G

| 1

USP49 activates anti-HIV-1 A3G. 1 / 1

| 1

➶

eidos

31397674

USP49 affects YARS2

1 |

USP49 binds YARS2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects Wnt/β-catenin

| 1

USP49 inhibits Wnt/β-catenin. 1 / 1

| 1

➶

reach

"USP49 attenuates OA progression by inhibiting the Wnt/β-catenin pathway."

34216299

USP49 affects Wnt

| 1

USP49 activates Wnt. 1 / 1

| 1

➶

reach

32737772

USP49 affects Ubiquitination

| 1

USP49 inhibits Ubiquitination. 1 / 1

| 1

➶

eidos

"The authors further demonstrated that USP49 interacted with A3G and reduced its ubiquitination ."

31397674

USP49 affects USP7

| 1

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

USP49 affects UBR5

1 |

UBR5 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects U2 snRNPs

| 1

USP49 inhibits U2 snRNPs. 1 / 1

| 1

➶

reach

"Depletion of the H2B deubiquitinase, USP49 caused extensive changes in alternative splicing marked by preferential skipping of exons with elevated H2Bub1 and reduced association of the U1 and U2 snRNPs with chromatin 130."

27107644

USP49 affects TRIM35

1 |

TRIM35 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP49 affects TP53BP1

| 1

USP49 inhibits TP53BP1. 1 / 1

| 1

➶

reach

"Consequently, over-expression of USP49 inhibited the DSB-induced foci formation of 53BP1 and resulted in higher cell sensitivity to DSB-inducing drug treatment."

35598681

USP49 affects Stomach Neoplasms

| 1

USP49 activates Stomach Neoplasms. 1 / 1

| 1

➶

reach

35318441

USP49 affects STIP1

1 |

STIP1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects STING aggregation

| 1

USP49 inhibits STING aggregation. 1 / 1

| 1

➶

eidos

"On the contrary , USP49 antagonizes STING activation by removing its K63-linked ubiquitin chains , impedes STING aggregation , and subsequent TBK1 recruitment after HSV-1 invasion ( Ye et al ., 2019 ) ."

34966372

USP49 affects STAMBPL1

1 |

USP49 binds STAMBPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects SOX2

| 1

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

USP49 affects SLC39A7

1 |

USP49 binds SLC39A7. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects SHPRH

1 |

SHPRH binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects SHCBP1

1 |

USP49 binds SHCBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects RPN1

1 |

RPN1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects RBCK1

1 |

RBCK1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

USP49 affects R-induced apoptosis H9c2 cardiomyocytes

| 1

USP49 inhibits R-induced apoptosis H9c2 cardiomyocytes. 1 / 1

| 1

➶

eidos

"35 Some studies have found that ubiquitin-specific peptidase 49 ( USP49 ) and 2,3,5,4 - tetrahydroxystilbene-2-O-beta-d-glucoside ( TSG ) could eliminate the I / R-induced apoptosis of H9c2 cardiomyocytes ,36 while miR-181c-5p exacerbated the hypoxia / reoxygenation ( H / R ) - induced apoptosis of H9c2 cells by targeting PTPN4.37 Nevertheless , no significant progress has been achieved to eliminate I / R injury and MI after decades of investigation ."

33717651

USP49 affects Pulmonary Disease, Chronic Obstructive

| 1

USP49 activates Pulmonary Disease, Chronic Obstructive. 1 / 1

| 1

➶

reach

"PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke Induced COPD by Integrative Bioinformatics Analysis."

33116468

USP49 affects Prognosis

| 1

USP49 inhibits Prognosis. 1 / 1

| 1

➶

eidos

"USP49 mediates tumor progression and poor prognosis through a YAP1-dependent feedback loop in gastric cancer ."

35318441

USP49 affects PRKACA

1 |

USP49 binds PRKACA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PPP6R3

1 |

PPP6R3 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PPP6R2

1 |

PPP6R2 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PPP6R1

1 |

USP49 binds PPP6R1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PPP5C

1 |

USP49 binds PPP5C. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PPM1G

1 |

USP49 binds PPM1G. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PHLPP1

| 1

USP49 inhibits PHLPP1. 1 / 1

| 1

➶

reach

"In contrast, another DUB, USP49, inhibits AKT pathway by promoting interaction of PHLPP1 to AKT, thus facilitating the de-phosphorylation of AKT."

28923280

USP49 affects PDCD2

1 |

USP49 binds PDCD2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects PAX9 MSX1 proteins

| 1

USP49 activates PAX9 MSX1 proteins. 1 / 1

| 1

➶

eidos

"On the other hand , the loss of USP49 reduces the levels of PAX9 and MSX1 proteins , which causes transient retardation of odontogenic differentiation in human dental pulp stem cells and delays the differentiation of human pluripotent stem cells into the neural crest cell lineage ."

35273362

USP49 affects Neoplasm Metastasis

| 1

USP49 activates Neoplasm Metastasis. 1 / 1

| 1

➶

reach

35318441

USP49 affects NUP85

1 |

USP49 binds NUP85. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects NEK6

| 1

USP49 binds NEK6. 1 / 1

| 1

➶

sparser

"However, we found that NEK6 specifically interacted with USP49 but not NEK3, suggesting that NEK6 was critically involved in USP49 degradation (Supplementary Fig. xref )."

35279684

USP49 affects MED8

1 |

MED8 binds USP49. 1 / 1

1 |

➶

hprd

No evidence text available

14576168

USP49 affects MED18

1 |

USP49 binds MED18. 1 / 1

1 |

➶

hprd

No evidence text available

12584197

USP49 affects MED17

1 |

USP49 binds MED17. 1 / 1

1 |

➶

hprd

No evidence text available

14576168

USP49 affects MCM6

1 |

USP49 binds MCM6. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects LRPPRC

1 |

LRPPRC binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects LONG-NON-CODING-RNA

| 1

USP49 binds LONG-NON-CODING-RNA. 1 / 1

| 1

➶

trips

"The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49."

32691951

USP49 affects KRR1

1 |

USP49 binds KRR1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects JNK

| 1

USP49 activates JNK. 1 / 1

| 1

➶

reach

"Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes."

30246457

USP49 affects IPO9

1 |

IPO9 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects IPO7

1 |

USP49 binds IPO7. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects IL1B

| 1

USP49 decreases the amount of IL1B. 1 / 1

| 1

➶

reach

34216299

USP49 affects Hemagglutinins

| 1

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

USP49 affects HUWE1

1 |

USP49 binds HUWE1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects HIV-1 replication

| 1

USP49 inhibits HIV-1 replication. 1 / 1

| 1

➶

eidos

"Thank you for submitting your article `` USP49 potently stabilizes APOBEC3G protein and inhibits HIV-1 replication '' for consideration by eLife ."

31397674

USP49 affects HIV infectivity

| 1

USP49 inhibits HIV infectivity. 1 / 1

| 1

➶

eidos

"It is important to show that USP49 works with the endogenous A3G to inhibit HIV infectivity ."

31397674

USP49 affects HADHA

1 |

USP49 binds HADHA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects H2Bub

| 1

USP49 inhibits H2Bub. 1 / 1

| 1

➶

reach

"USP49 knockout increased the H2Bub enrichment at MDM2 gene whereas USP49 overexpression downregulated the H2Bub level at MDM2 gene."

35072515

USP49 affects H2BC10

1 |

USP49 deubiquitinates H2BC10. 1 / 1

1 |

➶

ubibrowser

"USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing"

23824326

USP49 affects H2AX

| 1

USP49 leads to the deubiquitination of H2AX. 1 / 1

| 1

➶

reach

"Over-expressed USP49 suppressed ubiquitylation of γH2AX in an enzymatic activity-dependent manner."

35598681

USP49 affects GST

| 1

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

USP49 affects FKBP51-AKT

| 1

USP49 activates FKBP51-AKT. 1 / 1

| 1

➶

reach

"USP49 is also reported to suppress tumorigenesis and chemo-responses in pancreatic cancer by targeting FKBP51-AKT signaling 29."

29748582

USP49 affects F7

1 |

USP49 binds F7. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects DNA Breaks, Double-Stranded

| 1

USP49 inhibits DNA Breaks, Double-Stranded. 1 / 1

| 1

➶

reach

"Consequently, over-expression of USP49 inhibited the DSB-induced foci formation of 53BP1 and resulted in higher cell sensitivity to DSB-inducing drug treatment."

35598681

USP49 affects DKK1

| 1

USP49 activates DKK1. 1 / 1

| 1

➶

reach

"Zc3h11a, Rnasek, Usp49, Btbd6, and Ly6c1 were the 5 most highly upregulated genes upon treatment with DKK1 (Supplemental Figure 8D)."

34847079

USP49 affects DICER1

1 |

DICER1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects Carcinoma, Non-Small-Cell Lung

| 1

USP49 inhibits Carcinoma, Non-Small-Cell Lung. 1 / 1

| 1

➶

reach

"USP49 was also reported to inhibit non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling ."

34075026

USP49 affects Carcinogenesis

| 1

USP49 inhibits Carcinogenesis. 1 / 1

| 1

➶

reach

34075026

USP49 affects CTNNB1

| 1

USP49 activates CTNNB1. 1 / 1

| 1

➶

reach

32737772

USP49 affects COPA

1 |

USP49 binds COPA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects CETN3

1 |

CETN3 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects CETN2

1 |

CETN2 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects CETN1

1 |

CETN1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects ANKRD52

1 |

USP49 binds ANKRD52. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP49 affects ANKRD28

1 |

USP49 binds ANKRD28. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

USP44 affects USP7

| 1

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

UBR5 affects USP49

1 |

UBR5 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Treating primary rat chondrocytes different IL-1beta affects USP49

| 1

Treating primary rat chondrocytes different IL-1beta inhibits USP49. 1 / 1

| 1

➶

eidos

"Treating primary rat chondrocytes with different concentrations of IL-1beta resulted in decreased Usp49 expression , while Usp49 overexpression could attenuate IL-1beta-induced chondrocyte apoptosis by promoting Axin deubiquitination ."

32737772

TRIM35 affects USP49

1 |

TRIM35 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

TP53 affects Hemagglutinins

| 1

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

TP53 affects GST

| 1

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

TNF affects USP49

| 1

TNF activates USP49. 1 / 1

| 1

➶

reach

"Nonetheless, a minimum of two siRNA molecules led to increased levels of nuclear NF-kappaB in A549 cells depleted of A20, USP7, USP49, USP54, or FBXO36 and treated with TNF for 120min."

25071782

TFAP2C affects USP49

1 |

TFAP2C decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

TFAP2A affects USP49

1 |

TFAP2A decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

Soman affects USP49

1 |

Soman increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

19281266

STIP1 affects USP49

1 |

STIP1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

STAMBPL1 affects USP49

1 |

USP49 binds STAMBPL1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SOX2 affects USP7

| 1

SOX2 binds USP25, USP7, USP44, and USP49. 1 / 1

| 1

➶

sparser

"USP25, USP44, USP49, and USP7 bind to the Sox2 promoter, while USP10, USP16, USP3, USP37, USP44, and USP7 bind to the Nanog promoter."

26880980

SLC39A7 affects USP49

1 |

USP49 binds SLC39A7. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SHPRH affects USP49

1 |

SHPRH binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

SHCBP1 affects USP49

1 |

USP49 binds SHCBP1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RUVBL1 affects PSMC5

| 1

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

➶

sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

RPN1 affects USP49

1 |

RPN1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

RNAi affects USP49

| 1

RNAi activates USP49. 1 / 1

| 1

➶

reach

"qPCR data suggest that RNAi mediated inactivation of USP49, FBXO36, and USP12 depleted levels of the corresponding transcripts."

25071782

REPIN1 affects USP49

1 |

REPIN1 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

RBCK1 affects USP49

1 |

RBCK1 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

23105109

PSMC5 affects RUVBL1, and USP49

| 1

RUVBL1 binds USP49 and PSMC5. 1 / 1

| 1

➶

sparser

"USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo."

23824326

PRKACA affects USP49

1 |

USP49 binds PRKACA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPP6R3 affects USP49

1 |

PPP6R3 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPP6R2 affects USP49

1 |

PPP6R2 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPP6R1 affects USP49

1 |

USP49 binds PPP6R1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPP5C affects USP49

1 |

USP49 binds PPP5C. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PPM1G affects USP49

1 |

USP49 binds PPM1G. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PDCD2 affects USP49

1 |

USP49 binds PDCD2. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

PCB 180 affects USP49

1 |

PCB 180 increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

25510870

PAX9 affects USP49

| 1

USP49 binds PAX9. 1 / 1

| 1

➶

reach

"We identify and demonstrate that USP49 interacts with and deubiquitinates PAX9 and MSX1, thereby extending their protein half-lives."

35273362

NUP85 affects USP49

1 |

USP49 binds NUP85. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

NSC 689534 affects USP49

1 |

NSC 689534 increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

20971185

N-methyl-4-phenylpyridinium affects USP49

1 |

N-methyl-4-phenylpyridinium increases the amount of USP49. 1 / 1

1 |

➶

ctd

No evidence text available

28801915

MYOD1 affects USP49

1 |

MYOD1 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

MED8 affects USP49

1 |

MED8 binds USP49. 1 / 1

1 |

➶

hprd

No evidence text available

14576168

MED18 affects USP49

1 |

USP49 binds MED18. 1 / 1

1 |

➶

hprd

No evidence text available

12584197

MED17 affects USP49

1 |

USP49 binds MED17. 1 / 1

1 |

➶

hprd

No evidence text available

14576168

MDM2 affects USP49

| 1

USP49 binds MDM2. 1 / 1

| 1

➶

sparser

"Moreover, chromatin immunoprecipitation revealed that USP49 directly bound to the promoter of MDM2 gene."

35072515

MCM6 affects USP49

1 |

USP49 binds MCM6. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

LRPPRC affects USP49

1 |

LRPPRC binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

LONG-NON-CODING-RNA affects USP49

| 1

USP49 binds LONG-NON-CODING-RNA. 1 / 1

| 1

➶

trips

"The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49."

32691951

KRR1 affects USP49

1 |

USP49 binds KRR1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

IPO9 affects USP49

1 |

IPO9 binds USP49. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

IPO7 affects USP49

1 |

USP49 binds IPO7. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

Histone_H2B affects USP49

| 1

Histone_H2B activates USP49. 1 / 1

| 1

➶

reach

"Correction for Shi et al., "USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis"."

35546121

Hemagglutinins affects USP49

| 1

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

HUWE1 affects USP49

1 |

USP49 binds HUWE1. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

HLNC1-USP49 interaction affects USP49

| 1

HLNC1-USP49 interaction inhibits USP49. 1 / 1

| 1

➶

eidos

"HLNC1-USP49 interaction dramatically destabilized USP49 ."

32691951

HAND1 affects USP49

1 |

HAND1 decreases the amount of USP49. 1 / 1

1 |

➶

biopax:msigdb

No evidence text available

HADHA affects USP49

1 |

USP49 binds HADHA. 1 / 1

1 |

➶

biogrid

No evidence text available

19615732

H2BC21 affects USP49

1 |

USP49 binds H2BC21. 1 / 1

1 |

➶

biogrid

No evidence text available

23824326

GST affects USP49

| 1

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582

Flag affects Hemagglutinins, TP53, and USP49

| 1

TP53 binds USP49, Hemagglutinins, and Flag. 1 / 1

| 1

➶

sparser

29748582

Flag affects GST, TP53, and USP49

| 1

GST binds TP53, USP49, and Flag. 1 / 1

| 1

➶

sparser

"This interaction was further confirmed in a GST pull-down assay, with GST-p53 specifically interacting with transfected Flag-USP49, as shown in Fig. xref ."

29748582