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USP49 deubiquitinates PAX9. 7 / 7
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"We identify and demonstrate that USP49 interacts with and deubiquitinates PAX9 and MSX1, thereby extending their protein half-lives."
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"In sum, our results suggest that deubiquitination of PAX9 and MSX1 by USP49 stabilizes their protein levels to facilitate successful odontogenesis."
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"USP49 deubiquitinates PAX9 and MSX1 proteins."
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"USP49 significantly decreased the polyubiquitination of both endogenous PAX9 (Fig. 4B, lane 2) and MSX1 (Fig. 4E, lane 2), as well as exogenous PAX9 (Fig. 4C, lane 4) and MSX1 (Fig. 4F, lane 4)."
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"However, no deubiquitinating activity was observed for PAX9 and MSX1 proteins in the presence of USP49CA (Fig. 4B, lane 3; 4E, lane 3; Fig. 4C, lane 5; Fig. 4F, lane 5), upon knockdown of USP49 (Fig. 4B, lane 4; 4E, lane 4; Fig. 4C, lane 6; Fig. 4F, lane 6), USP44, a paralog of USP49 [38] (Supplementary Fig. S9A, B, lane 6), indicating that USP49 deubiquitinates PAX9 and MSX1."
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"Importantly, the loss of USP49 promoted the polyubiquitination of PAX9 and MSX1, thereby triggering rapid protein degradation (Fig. 4)."
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"Here, we demonstrated that USP49 with the UCH domain at the C-terminus is necessary for the interaction and deubiquitination of PAX9 and MSX1."
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