IndraLab

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USP49 inhibits PI3K. 4 / 4
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"USP49 was also reported to inhibit non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling ."
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"As shown in Fig. 6D, overexpression of USP49 significantly inhibited cell proliferation and reversed the promotion effect of miR-5000-3p on cell proliferation ability.Due to USP49 was involved in the PI3K/AKT signaling pathway ."
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"In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling."
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"Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells."
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