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USP49 decreases the amount of MSX1. 4 / 4
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"On the other hand, the loss of USP49 reduces the levels of PAX9 and MSX1 proteins, which causes transient retardation of odontogenic differentiation in human dental pulp stem cells and delays the differentiation of human pluripotent stem cells into the neural crest cell lineage."
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"Moreover, immunostaining showed a complete reduction in USP49 expression in the USP49 KO-clone, which reduced PAX9 and MSX1 expression (Fig. 6C)."
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"Disruption of USP13 and USP49 genes reduced PAX9 protein, and USP11 and USP49 disruption reduced MSX1 protein levels (Fig. 1A)."
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"USP49 expression was significantly reduced in USP49 KO-clone#28, resulting in reduced PAX9 and MSX1 expression in USP49 KO-clone#28 compared with the mock control (Supplementary Fig. S12G)."
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